Advances in the research of intestinal fungi in Crohn's disease  

作　　者：Mo-Wei Kong Yang Yu Peng Wang Ying Wan Yu Gao Chun-Xiang Zhang 

机构地区：[1]Department of Cardiology,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan Province,China [2]Department of General Surgery,Xinqiao Hospital,Army Medical University,Chongqing 400037,China [3]School of Basic Medical Sciences,Southwest Medical University,Luzhou 646000,Sichuan Province,China [4]Department of Endocrinology,Affiliated Hospital of Chengde Medical University,Chengde 067000,Hebei Province,China

出　　处：《World Journal of Gastroenterology》2024年第39期4318-4323,共6页世界胃肠病学杂志（英文）

基　　金：Supported by National Natural Science Foundation of China,No.U23A20398 and No.82030007;Sichuan Science and Technology Program,No.2022YFS0578.

摘　　要：This article reviews of the original research published by Wu et al in the World Journal of Gastroenterology,delving into the pivotal role of the gut microbiota in the pathogenesis of Crohn's disease(CD).Insights were gained from fecal microbiota transplantation(FMT)in mouse models,revealing the intricate interplay between the gut microbiota,mesenteric adipose tissue(MAT),and creeping fat.The study uncovered the characteristics of inflammation and fibrosis in the MAT and intestinal tissues of patients with CD;moreover,through the FMT mouse model,it observed the impact of samples from healthy patients and those with CD on symptoms.The pathogenesis of CD is complex,and its etiology remains unclear;however,it is widely believed that gut microbiota dysbiosis plays a significant role.Recently,with the development and application of next-generation sequen-cing technology,research on the role of fungi in the pathogenesis and chronicity of CD has deepened.This editorial serves as a supplement to the research by Wu et al who discussed advances related to the study of fungi in CD.

关 键 词：Intestinal microbiota Crohn's disease pathogenesis Fecal microbiota trans-plantation Mesenteric adipose tissue Gut fungal dynamics 

分 类 号：R574[医药卫生—消化系统]