Microbiome as an endocrine organ and its relationship with eye diseases:Effective factors and new targeted approaches  

作　　者：Leila Haghshenas Sara Banihashemi Yalda Malekzadegan Roberto Catanzaro Amir Moghadam Ahmadi Francesco Marotta 

机构地区：[1]Department of Clinical Bioinformatics,Harvard Medical School,Boston,MA 02115,United States [2]Department of Bioscience,School of Science and Technology,Nottingham Trend University,Nottingham NG14FQ,United KingdomDepartment of Bioscience,School of Science and Technology,Nottingham Trend University,Nottingham NG14FQ,United Kingdom [3]Department of Microbiology,Saveh University of Medical Sciences,Saveh 3919676651,Iran [4]Department of Clinical and Experimental Medicine,University of Catania,Catania 95123,Catania,Italy [5]Department of Neuroimmunology,Thomas Jefferson University Hospital,Philadelphia,PA 19107,United States [6]Department of Human Nutrition and Food Sciences,Texas Women University,Milano 20154,Italy

出　　处：《World Journal of Gastrointestinal Pathophysiology》2024年第5期1-18,共18页世界胃肠病理生理学杂志（英文）

摘　　要：Microbiome is an endocrine organ that refers to both the complicated biological system of microbial species that colonize our bodies and their genomes and surroundings.Recent studies confirm the connection between the microbiome and eye diseases,which are involved in the pathogenesis of eye diseases,including age-related macular disorders,diabetic retinopathy,glaucoma,retinitis pigmentosa,dry eye,and uveitis.The aim of this review is to investigate the microbiome in relation to eye health.First,a brief introduction of the characteristics of the gut microorganisms terms of composition and work,the role of dysbiosis,the gut microbiome and the eye microbiome in the progression of eye illnesses are highlighted,then the relationship among the microbiome and the function of the immune system and eye diseases,the role of inflammation and aging and the immune system,It has been reviewed and finally,the control and treatment goals of microbiome and eye diseases,the role of food factors and supplements,biotherapy and antibiotics in relation to microbiome and eye health have been reviewed.

关 键 词：DYSBIOSIS Gut microbiome Eye diseases Inflammation Diabetic retinopatyhy Aging Nutrient supplementation 

分 类 号：R58[医药卫生—内分泌] R77[医药卫生—内科学]