A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients  

作　　者：Ji Yeong An Sung Eun Oh Soomin Ahn Hyoung-II Kim Yoo Min Kim Minah Cho Keun Won Ryu Hong Man Yoon Young Kyu Park In Gyu Kwon Sung Hoon Noh Kyung Hee Lee In Cho Myoung Won Son Jong Won Kim Young-Woo Kim 

机构地区：[1]Department of Surgery,Samsung Medical Center,Sungkyunkwan University School of Medicine,Seoul 06351,Republic of Korea [2]Department of Pathology and Translational Genomics,Samsung Medical Center,Sungkyunkwan University School of Medicine,Seoul 06351,Republic of Korea [3]Department of Surgery,Yonsei University College of Medicine,Seoul 03722,Republic of Korea [4]Gastric Cancer Center,Yonsei Cancer Center,Yonsei University Health System,Seoul 03722,Republic of Korea [5]Center for Gastric Cancer,National Cancer Center,Goyang 10408,Republic of Korea [6]Department of Surgery,Chonnam National University Hwasun Hospital,Chonnam National University College of Medicine,Gwangju 58128,Republic of Korea [7]Department of Surgery,Gangnam Severance Hospital,Yonsei University College of Medicine,Seoul 06273,Republic of Korea [8]Department of Hematology-Oncology,Yeungnam University Medical Center,Daegu 42415,Republic of Korea [9]Department of Surgery,Soonchunhyang University College of Medicine,Bucheon 14584,Republic of Korea [10]Department of Surgery,Soonchunhyang University Cheonan Hospital,Soonchunhyang University College of Medicine,Cheonan 31151,Republic of Korea [11]Department of Surgery,Chung-Ang University Hospital,Chung-Ang University College of Medicine,Seoul 06973,Republic of Korea

出　　处：《Chinese Journal of Cancer Research》2024年第4期368-377,共10页中国癌症研究（英文版）

基　　金：partial financial support provided by Novomics (Seoul, Korea)

摘　　要：Objective:Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy decisions.In this study,we evaluated the clinical feasibility of the single patient classifier(SPC)test,a new clinical-grade prognostic assay,in stageⅡ-Ⅲgastric cancer patients.Methods:A prospective multicenter study was conducted,involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine hospitals.The SPC test was employed to stratify patients into risk groups,and its feasibility and performance were evaluated.The primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative treatment.Furthermore,3-year disease-free survivals of risk groups were analyzed.Results:The SPC test met the primary endpoint criteria.The 99.5%of SPC tests were timely delivered to hospitals before the postoperative treatment started.In a clinical setting,the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 d.Furthermore,3-year disease-free survivals were significantly different between risk groups classified with SPC tests.Conclusions:This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment strategies.It also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关 键 词：Prognostic test advanced gastric cancer adjuvant chemotherapy FEASIBILITY GASTRECTOMY 

分 类 号：R735.2[医药卫生—肿瘤]