三阴性乳腺癌组织中FSP1、PDGFRβ的表达及其与临床病理特征的相关性  

Expression of FSP1 and PDGFRβ in triple negative breast cancer tissue and their correlations with clinicopathological characteristics

作　　者：李静[1] 李孟圈[1] Li Jing;Li Mengquan(Department of Breast Surgery I,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院乳腺外一科,郑州450052

出　　处：《中国实用医刊》2024年第16期20-23,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨成纤维细胞特异性蛋白1(FSP1)、血小板衍生生长因子受体β(PDGFRβ)在三阴性乳腺癌患者中的表达及其与临床病理特征间的关系。方法回顾性抽取2019年8月至2022年8月郑州大学第一附属医院收治的62例三阴性乳腺癌患者开展研究,均行手术治疗,术中采集肿瘤及癌旁正常组织标本,行免疫组化链霉菌抗生物素蛋白-过氧化物酶连结法检测,统计肿瘤组织及癌旁正常组织内FSP1、PDGFRβ阳性表达情况,并分析FSP1、PDGFRβ表达与年龄、肿瘤长径、绝经状态、淋巴结转移、肿瘤分期、分化程度等病理特征间的关系。结果肿瘤组织内FSP1、PDGFRβ阳性表达率(70.97%,44/62;64.52%,40/62)高于癌旁正常组织(4.84%,3/62;3.23%,2/62),P<0.05。FSP1阳性表达患者中临床分期Ⅲ~Ⅳ期、高分化、肿瘤长径≥3 cm、有淋巴结转移者占比高于FSP1阴性表达患者(P<0.05);PDGFRβ阳性表达患者中临床分期Ⅲ~Ⅳ期、高分化、肿瘤长径≥3 cm、有淋巴结转移者占比高于PDGFRβ阴性表达患者(P<0.05)。结论FSP1、PDGFRβ在三阴性乳腺癌中阳性表达率高,与临床分期、分化程度、肿瘤长径及淋巴结转移关系密切,或可为临床治疗提供新的靶点。Objective To investigate the expression of fibroblast specific protein 1(FSP1)and platelet derived growth factor receptorβ(PDGFRβ)in triple negative breast cancer tissue and their correlations with clinicopathological characteristics.Methods Sixty-two patients with triple negative breast cancer admitted to the First Affiliated Hospital of Zhengzhou University from August 2019 to August 2022 were retrospectively selected for the study.They all received surgical treatment.Samples of tumor and normal tissues adjacent to cancer were collected during the operation,and immunohistochemical streptavidin-perosidase method was used to detect the expression of FSP1 and PDGFRβin tumor tissues and normal tissues adjacent to cancer.The correlations of expression of FSP1 and PDGFRβwith pathological characteristics,such as age,tumor major diameter,menopausal status,lymph node metastasis,tumor stage,and degree of differentiation were analyzed.Results The positive expression rates of FSP1 and PDGFRβin tumor tissues(70.97%,44/62;64.52%,40/62)were higher than those in adjacent normal tissues(4.84%,3/62;3.23%,2/62),P<0.05.The proportions of clinical stages III-IV,high differentiation,tumor major diameter≥3 cm,and lymph node metastasis among patients with FSP1 positive expression had a higher were higher than those among patients with FSP1 negative expression(P<0.05).Compared with patients with PDGFRβnegative expression,the proportions of clinical stages III-IV,high differentiation,tumor major diameter≥3 cm,and lymph node metastasis among patients with PDGFRβpositive expression were higher(P<0.05).Conclusions FSP1 and PDGFRβhave higher positive expression rate in patients with triple negative breast cancer.The two indicators are closely related to clinical stage,differentiation,tumor major diameter and lymph node metastasis,therefore,they may provide a new target for clinical treatment.

关 键 词：三阴性乳腺癌 成纤维细胞特异性蛋白1 血小板衍生生长因子受体β 临床表达 病理特征 

分 类 号：R737.9[医药卫生—肿瘤]