硬化剂瘤体内注射联合普萘洛尔口服治疗婴幼儿血管瘤的效果研究  

Effect of intranasal injection of sclerosing solutions combined with oral propranolol in the treatment of infantile hemangioma

作　　者：李欣露 张巧荣 左松 田笑绮 胡光珍 Li Xinlu;Zhang Qiaorong;Zuo Song;Tian Xiaoqi;Hu Guangzhen(Department of Hemangioma,Henan Provincial People's Hospital,Henan Provincial Key Laboratory of Nursing Medicine,People's Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]河南省人民医院血管瘤科、河南省护理医学重点实验室郑州大学人民医院,郑州450000

出　　处：《中国实用医刊》2024年第16期85-88,共4页Chinese Journal of Practical Medicine

摘　　要：目的研究硬化剂瘤体内注射联合普萘洛尔口服治疗婴幼儿血管瘤的效果。方法队列研究。抽取2022年1月至2023年6月河南省人民医院收治的82例血管瘤患儿,按随机数字表法分为单一组和联合组,每组41例。单一组予以口服普萘洛尔治疗,联合组予以硬化剂瘤体内注射联合普萘洛尔口服治疗。比较两组疗效、治愈时间、血流动力学指标(阻力指数、血管指数、血流峰值)及不良反应发生率。结果联合组总有效率(95.12%,39/41)高于单一组(68.29%,28/41),P<0.05;联合组痊愈时间短于单一组(P<0.05);治疗后,联合组阻力指数高于单一组,血管指数、血流峰值低于单一组(P<0.05);联合组不良反应发生率(9.76%,4/41)与单一组(24.39%,10/41)比较差异未见统计学意义(P>0.05)。结论瘤体内注射硬化剂联合普萘洛尔口服治疗婴幼儿血管瘤效果显著,能改善患儿血流动力学,缩短治疗时间,且安全性较高。Objective To investigate the effect of intranasal injection of sclerosing solutions combined with oral propranolol in the treatment of infantile hemangioma.Methods A total of 82 infants with hemangioma treated in Henan Provincial People’s Hospital from January 2022 to June 2023 were selected for the cohort study.And they were divided into a single group and a combined group using a random number table method,with 41 cases in each group.The single group was treated with oral propranolol,and the combined group was treated with intranasal injection of sclerosing solutions combined with oral propranolol.The curative effect,recovery time,hemodynamic indicators(resistance index,vascular index,peak blood flow),and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the combined group(95.12%,39/41)was higher than that of the single group(68.29%,28/41),P<0.05.The recovery time of the combined group was shorter than that of the single group(P<0.05).After treatment,the combined group had higher resistance index,lower vascular index and lower peak blood flow compared with the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the combined group(9.76%,4/41)and the single group(24.39%,10/41),P>0.05.Conclusions Intranasal injection of sclerosing solutions combined with oral propranolol is effective in the treatment of infantile hemangioma,which can improve the hemodynamics of children and shorten the treatment time,with high safety.

关 键 词：血管瘤 婴幼儿 普萘洛尔 硬化剂 

分 类 号：R732.2[医药卫生—肿瘤]