质子泵抑制剂预防骨科NSAIDs相关性胃黏膜损伤的合理性评价  

Rationality evaluation of proton pump inhibitors in preventing of NSAIDs related gastric mucosal injury in orthopedics

作　　者：陈贵芳 CHEN Guifang(Department of Pharmacy,Guiyang Yunyan District People′s Hospital,Guiyang,Guizhou 550000,China)

机构地区：[1]贵阳市云岩区人民医院药剂科,贵州贵阳550000

出　　处：《现代医药卫生》2024年第19期3295-3298,共4页Journal of Modern Medicine & Health

摘　　要：目的调查某院骨科患者使用质子泵抑制剂(PPIs)预防非甾体抗炎药(NSAIDs)相关性胃黏膜损伤的情况,评价其合理性,为PPIs的合理应用提供参考。方法采用回顾性调查研究的方法,收集该院2022年1月1日至12月31日骨科使用PPIs预防NSAIDs相关性胃黏膜损伤的患者信息,评价患者是否有PPIs预防性用药的指征,随后评价有用药指征病例的药物遴选、用药时机、用法用量、用药疗程等情况。结果307例患者中,62例(20.20%)患者无PPIs预防性用药的指征。245例次有用药指征病例产生不合理用药情况83例次(33.88%),主要为遴选药物不适宜、用药时机不适宜、用药频次不适宜、疗程过长。结论该院骨科使用PPIs预防NSAIDs相关性胃黏膜损伤不合理现象较为突出,医师应严格把控用药指征,药师应加强医嘱审核,共同促进药物合理使用。Objective To investigate the use of proton pump inhibitors(PPIs)for preventing non-steroidal anti-inflammatory drug(NSAID)related gastric mucosal injury in orthopedic patients and to evaluate its rationality,providing a reference for the proper use of PPIs.Methods A retrospective survey was conducted,collecting data from January 1,2022,to December 31,2022,on orthopedic patients who used PPIs to prevent NSAID-related gastric mucosal injury.The study assessed whether patients had indications for prophylactic use of PPIs and then evaluated the appropriateness of drug selection,timing of administration,dosage,and duration of treatment in cases with indications.Results Out of 307 patients,62(20.20%)did not have indications for prophylactic use of PPIs.Among the 245 instances where there were indications,83 instances(33.88%)involved inappropriate medication use,primarily due to unsuitable drug selection,inappropriate timing of administration,inappropriate frequency of administration,and excessively long treatment duration.Conclusion The inappropriate use of PPIs to prevent NSAID-related gastric mucosal injury in the orthopedics department is notable.Physicians should strictly control the indications for medication use,and pharmacists should enhance prescription review to jointly promote the rational use of drugs.

关 键 词：骨科 质子泵抑制剂 非甾体抗炎药相关性胃黏膜损伤 预防 合理用药 

分 类 号：R573[医药卫生—消化系统]