代谢相关脂肪性肝病诊治进展  

Advances in diagnosis and treatment of metabolic-associated fatty liver disease

作　　者：罗跃[1] 李永强(综述)[1] 周成会(审校) LUO Yue;LI Yongqiang;ZHOU Chenghui(Health Management Center,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Department of Liver,Gallbladder,Spleen and Stomach,Chongqing Traditional Chinese Medicine Hospital,Chongqing 400011,China)

机构地区：[1]重庆医科大学附属第一医院健康管理中心,重庆400016 [2]重庆市中医院肝胆脾胃科,重庆400011

出　　处：《现代医药卫生》2024年第19期3387-3391,共5页Journal of Modern Medicine & Health

摘　　要：非酒精性脂肪性肝病(NAFLD)是一组临床综合征,其病理特征与酒精性肝病相似,但患者没有过量饮酒史。NAFLD包括多种疾病,如单纯性脂肪肝、非酒精性脂肪性肝炎、脂肪性肝硬化以及肝细胞癌。非酒精性脂肪性肝炎是该病程发展的重要环节。此类疾病现已正式命名为代谢相关脂肪性肝病,并普遍认为该病的进程可以通过活动度和纤维化程度来精准描述。肝纤维化的出现对这类患者的预后有着重要影响。若不及时诊治,病情可能会逐步恶化,导致肝硬化及其相关并发症,甚至有可能发展成肝细胞癌。有效地预防和治疗代谢相关脂肪性肝病,有望进一步阻止慢性肝病的恶化,并降低肝硬化和肝病相关残疾及死亡的风险。Non-alcoholic fatty liver disease(NAFLD)is a clinical syndrome that exhibits similar histopathological changes in the liver as alcoholic liver disease,despite the absence of a history of excessive alcohol consumption in patients.It encompasses a range of conditions,including simple fatty liver,non-alcoholic steatohepatitis(NASH),fatty liver cirrhosis,and hepatocellular carcinoma.NASH represents a critical stage in the progression of this disease.Such diseases have been officially named as metabolic-associated fatty liver disease,and there is a general consensus that the progression of this disease can be accurately described by its activity and degree of fibrosis.The emergence of liver fibrosis has asignificant impact on the prognosis of these patients.Without timely diagnosis and treatment,the condition may gradually deteriorate,leading to liver cirrhosis and its associated complications,and there is even a possibility of developing hepatocellular carcinoma.Effective prevention and treatment of MAFLD have the potential to further halt the progression of chronic liver diseases and reduce the risks of liver cirrhosis,liver-related disabilities,and fatalities.

关 键 词：代谢相关脂肪性肝病 非酒精性脂肪性肝病 单纯性脂肪肝 综述 

分 类 号：R575.5[医药卫生—消化系统]