RELN基因与精神分裂症的关联性研究进展  

Research progress on the association between RELN gene and schizophrenia

作　　者：景琳霞 毛俊雄 张婷婷 马琦[3] 彭朕磊 袁慧博 伊琦忠[1] JING Linxia;MAO Junxiong;ZHANG Tingting;MA Qi;PENG Zhenglei;YUAN Huibo;YI Qizhong(Psychological Medicine Center,the First Affiliated Hospital of Xinjiang Medical University Xinjiang Clinical Medical Research Center of Mental Health State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,the Xinjiang Uygur Autonomous Region,Urumqi 830054,China;Department of Clinical Psychology,People’s Hospital of Changji Hui Autonomous Prefecture,the Xinjiang Uygur Autonomous Region,Changji 831199,China;Xinjiang Medical University Clinical Medical Research Institute,the Xinjiang Uygur Autonomous Region,Urumqi 830054,China;the Fourth People’s Hospital of Aksu Region,the Xinjiang Uygur Autonomous Region,Aksu 843099,China)

机构地区：[1]新疆医科大学第一附属医院心理医学中心,新疆精神(心理)临床医学研究中心,省部共建中亚高发病成因与防治国家重点实验室,新疆乌鲁木齐830054 [2]新疆维吾尔自治区昌吉回族自治州人民医院临床心理科,新疆昌吉831199 [3]新疆医科大学临床医学研究院,新疆乌鲁木齐830054 [4]新疆维吾尔自治区阿克苏地区第四人民医院,新疆阿克苏843099

出　　处：《中国医药导报》2024年第24期58-62,共5页China Medical Herald

基　　金：新疆维吾尔自治区自然科学基金资助项目(2022D01D64);国家自然科学基金资助项目(81960258)。

摘　　要：精神分裂症(SCZ)是一种严重、复杂的精神疾病,对公众健康产生极大影响,其病因至今尚未完全明确,可能与遗传、环境及神经发育异常等多种因素相关。RELN基因位于人类的7q22.1号染色体上,编码一种细胞外基质的丝氨酸蛋白RELN,该蛋白在大脑皮质及海马体中合成,参与神经元迁移和大脑新皮质发育。RELN及其信号通路异常可限制树突增殖、影响神经发生和突触传递,从而导致认知缺陷和大脑形态异常。既往基于多群体及动物实验研究表明,RELN基因是SCZ的重要候选基因。本文对RELN的功能特点、基因多态性及其在SCZ发生和发展中的研究进展进行综述,旨在进一步阐明RELN基因在SCZ发病机制中的潜在作用,为SCZ的诊治提供新思路。Schizophrenia(SCZ)is a serious and complex mental disorder that has a significant impact on public health,and its etiology has not been fully elucidated yet.It may be related to various factors such as genetics,environment,and abnormalities in neurodevelopment.RELN gene is located on chromosome 7q22.1 in humans,encoding a serine protein RELN in extracellular matrix.This protein is synthesized in cerebral cortex and hippocampus,and is involved in neuronal migration and the development of cerebral cortex.Abnormalities in RELN and its signaling pathway may limit dendritic proliferation,affect neurogenesis,and synaptic transmission,leading to cognitive deficits and brain morphological abnormalities.Previous studies based on diverse populations and animal experiments have indicated that RELN gene is an important candidate gene for SCZ.This article reviews functional characteristics of RELN,genetic polymorphisms,and research progress on its role in the development of SCZ,aiming to further elucidate the potential role of RELN gene in the pathogenesis of SCZ and provide new insights for diagnosis and treatment of SCZ.

关 键 词：RELN 神经发育 精神分裂症 基因多态性 信号通路 

分 类 号：R749.3[医药卫生—神经病学与精神病学]