Evidence-based orthobiologic practice:Current evidence review and future directions  

作　　者：Madhan Jeyaraman Naveen Jeyaraman Swaminathan Ramasubramanian Sangeetha Balaji Sathish Muthu 

机构地区：[1]Department of Orthopedics,ACS Medical College and Hospital,Dr MGR Educational and Research Institute,Chennai 600077,Tamil Nadu,India [2]Department of Research Methods,Orthopedic Research Group,Coimbatore 641045,Tamil Nadu,India [3]Department of Orthopedic,Government Medical College,Omandurar Government Estate,Chennai 600002,Tamil Nadu,India [4]Department of Orthopedics,Government Medical College and Hospital,Karur 639004,Tamil Nadu,India [5]Department of Biotechnology,Faculty of Engineering,Karpagam Academy of Higher Education,Coimbatore 641021,Tamil Nadu,India

出　　处：《World Journal of Orthopedics》2024年第10期908-917,共10页世界骨科杂志（英文）

摘　　要：The field of orthopedic and regenerative medicine is rapidly evolving with the increasing utilization of orthobiologic.These biologically derived therapies,inc-luding platelet-rich plasma,mesenchymal stem cells,bone marrow aspirate con-centrate,stromal vascular fraction(SVF),and autologous chondrocyte implanta-tion,are gaining traction for their potential to enhance the body's natural healing processes.They offer a promising alternative to traditional surgical interventions for musculoskeletal injuries and degenerative conditions.Current evidence su-ggests significant benefits of orthobiologics in treating conditions like osteoarth-ritis,tendon injuries,and spinal disorders,yet inconsistencies in treatment pro-tocols and outcomes persist.The global market for orthobiologics is projected to grow substantially,driven by advancements in biologic therapies such as adipose-derived stem cells and SVF,and the demand for minimally invasive treatments.Despite their promise,regulatory and ethical challenges,as well as the need for high-quality,standardized research,remain significant obstacles.Future dire-ctions in the field include advancements in delivery systems,personalized medi-cine approaches,and the exploration of novel sources like induced pluripotent stem cells,aiming for more targeted and effective treatments.Collaborative efforts are crucial to overcoming these challenges and ensuring the safe and effective application of orthobiologics in clinical practice.

关 键 词：Orthobiologics Platelet-rich plasma Stem cells Musculoskeletal regeneration Regenerative medicine Evidence-based medicine 

分 类 号：R741[医药卫生—神经病学与精神病学]