Viral-host molecular interactions and metabolic modulation:Strategies to inhibit flaviviruses pathogenesis  

作　　者：Zeeshan Ahmad Khan Mukesh Kumar Yadav Dong-Woo Lim Hojun Kim Jing-Hua Wang AbuZar Ansari 

机构地区：[1]Biohealth Products Research Center(BPRC),Research Center for Agedlife Redesign(RCAR),Department of Physical Therapy,INJE University,Gimhae 5084,South Korea [2]Department of Microbiology,Central University of Punjab,Bathinda 151401,India [3]Department of Diagnostics,College of Korean Medicine,Dongguk University,Goyang 10326,South Korea [4]Division of Rehabilitation Medicine of Korean Medicine,Department of Oriental Rehabilitation Medicine,Dongguk University,Ilsan Hospital,Goyang 10326,South Korea [5]Institute of Oriental Medicine,Dongguk University,Goyang 10326,South Korea [6]Department of Obstetrics and Gynecology,Ewha Womans University,Seoul 07985,South Korea

出　　处：《World Journal of Virology》2024年第4期41-50,共10页世界病毒学杂志（英文）

基　　金：Supported by The South Korea Health Technology R and D Project through the South Korea Health Industry Development Institute,Funded by the Ministry of Health and Welfare,South Korea,No.HF20C0020.

摘　　要：Flaviviruses,which include globally impactful pathogens,such as West Nile virus,yellow fever virus,Zika virus,Japanese encephalitis virus,and dengue virus,contribute significantly to human infections.Despite the ongoing emergence and resurgence of flavivirus-mediated pathogenesis,the absence of specific therapeutic options remains a challenge in the prevention and treatment of flaviviral infections.Through the intricate processes of fusion,transcription,replication,and maturation,the complex interplay of viral and host metabolic interactions affects pathophysiology.Crucial interactions involve metabolic molecules,such as amino acids,glucose,fatty acids,and nucleotides,each playing a pivotal role in the replication and maturation of flaviviruses.These viral-host metabolic molecular interactions hijack and modulate the molecular mechanisms of host metabolism.A comprehensive understanding of these intricate metabolic pathways offers valuable insights,potentially unveiling novel targets for therapeutic interventions against flaviviral pathogenesis.This review emphasizes promising avenues for the development of therapeutic agents that target specific metabolic molecules,such as amino acids,glucose,fatty acids,and nucleotides,which interact with flavivirus replication and are closely linked to the modulation of host metabolism.The clinical limitations of current drugs have prompted the development of new inhibitory strategies for flaviviruses based on an understanding of the molecular interactions between the virus and the host.

关 键 词：FLAVIVIRUS Nonstructural proteins Virus-host interaction Metabolism Inhibitors Vaccines 

分 类 号：Q51[生物学—生物化学]