Association between 5-HTR1A gene C-1019G polymorphism and antidepressant response in patients with major depressive disorder:A meta-analysis  

作　　者：Huai-Neng Wu Shuang-Yue Zhu Li-Na Zhang Bian-Hong Shen Lian-Lian Xu 

机构地区：[1]Department of Psychiatry,Affiliated Mental Health Center and Hangzhou Seventh People’s Hospital,Zhejiang University School of Medicine,Hangzhou 310013,Zhejiang Province,China

出　　处：《World Journal of Psychiatry》2024年第10期1573-1582,共10页世界精神病学杂志（英文）

摘　　要：BACKGROUND Major depressive disorder(MDD)is a substantial global health concern,and its treatment is complicated by the variability in individual response to antide-pressants.AIM To consolidate research and clarify the impact of genetic variation on MDD treatment outcomes.METHODS Adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines,a systematic search across PubMed,EMBASE,Web of Science,and the Cochrane Library was conducted without date restrictions,utilizing key terms related to MDD,serotonin 1A receptor polymorphism(5-HTR1A),C-1019G polymorphism,and antidepressant response.Studies meeting inclusion criteria were thoroughly screened,and quality assessed using the Newcastle-Ottawa Scale.Statistical analyses,includingχ2 and I²values,were used to evaluate heterogeneity and fixed-effect or random-effect models were applied accordingly.RESULTS The initial search yielded 1216 articles,with 11 studies meeting criteria for inclusion.Analysis of various genetic models showed no significant association between the 5-HTR1A C-1019G polymorphism and antidepressant efficacy.The heterogeneity was low to moderate,and no publication bias was detected through funnel plot symmetry and Egger's and Begg's tests.CONCLUSION This meta-analysis does not support a significant association between the 5-HTR1A C-1019G polymorphism and the efficacy of antidepressant treatment in MDD.The findings call for further research with larger cohorts to substantiate these results and enhance the understanding of antidepressant pharmacogenetics.

关 键 词：Major depressive disorder Antidepressant efficacy 5-HTR1A gene C-1019G polymorphism META-ANALYSIS 

分 类 号：R749.4[医药卫生—神经病学与精神病学]