Mechanism of imipenem-induced mental disorder: A meta-analysis  

作　　者：Zhou-Hong Zhan Jia-Liang Wang Li-Hong Wang Nan-Nan Shen Xin-Wen Liu Yan-Na Yu Fu-Rong Liu 

机构地区：[1]Department of Clinical Pharmacy,Affiliated Hospital of Shaoxing University,Shaoxing 312000,Zhejiang Province,China

出　　处：《World Journal of Psychiatry》2024年第10期1583-1591,共9页世界精神病学杂志（英文）

基　　金：Supported by the Education Research Program Project of Zhejiang Province,No.Y202043224.

摘　　要：BACKGROUND Imipenem is a highly effective carbapenem antibiotic,which is widely used in the treatment of many serious bacterial infections.At the same time,it can also cause some adverse reactions,mental abnormalities are the most concerned central nervous system adverse reactions.Different patients respond differently to imipenem,and the effect of imipenem on psychiatric disorders is unclear.Therefore,meta-analysis summarizing the results of multiple previous studies can provide stronger evidence support for clinical guidelines to guide clinical rational use of imipenem to minimize risks.After reviewing the literature published between 2003 and 2017,seven controlled trials with a total of 550 patients were included,with 273 and 277 patients in the control and experimental groups,respectively.The sample size of the study ranged from a minimum of 30 cases to a maximum of 61 cases.Patients in the experimental group were treated with imipenem while the control group was treated with conventional drugs.Meta-analysis showed that the incidence of mental disorders in the experimental group was higher than that in the control group(odds ratio=3.66,95%confidence interval:1.11-12.11,P=0.030);however,there was no significant difference in the incidence of adverse reactions between the two groups(odds ratio=0.05,95%confidence interval:0.00 to 0.10,P=0.060).Funnel diagrams showed that the scattered points of each study were symmetrical and distributed in an inverted funnel shape;therefore,there was no publication bias.CONCLUSION Imipenem can cause mental disorders in patients.However,the low quality of the included literature may have affected the final results.Therefore,it is necessary to conduct a high-quality randomized controlled study with multiple samples to further confirm the mechanism of imipenem-induced mental disorders and provide effective guidance for clinical treatment.

关 键 词：Imipenem PSYCHOSIS Drug mechanism Meta analysis Document resource quality 

分 类 号：R749[医药卫生—神经病学与精神病学]