Update understanding on diagnosis and histopathological examination of atrophic gastritis:A review  

作　　者：Xiu-Zhen Ma Ni Zhou Xiu Luo Si-Qi Guo Ping Mai 

机构地区：[1]The First School of Clinical Medicine,Lanzhou University,Lanzhou 730000,Gansu Province,China [2]Department of Gastroenterology,Gansu Provincial People's Hospital,Lanzhou 730000,Gansu Province,China [3]Department of Gastroenterology,Xi'an International Medical Center,Xi’an 710000,Shaanxi Province,China [4]The First School of Clinical Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2024年第10期4080-4091,共12页世界胃肠肿瘤学杂志（英文）

摘　　要：Chronic atrophic gastritis(CAG)is a complex syndrome in which long-term chronic inflammatory stimulation causes gland atrophy in the gastric mucosa,reducing the stomach's ability to secrete gastric juice and pepsin,and interfering with its normal physiological function.Multiple pathogenic factors contribute to CAG incidence,the most common being Helicobacter pylori infection and the immune reactions resulting from gastric autoimmunity.Furthermore,CAG has a broad spectrum of clinical manifestations,including gastroenterology and extraintestinal symptoms and signs,such as hematology,neurology,and oncology.Therefore,the initial CAG evaluation should involve the examination of clinical and serological indicators,as well as diagnosis confirmation via gastroscopy and histopathology if necessary.Depending on the severity and scope of atrophy affecting the gastric mucosa,a histologic staging system(Operative Link for Gastritis Assessment or Operative Link on Gastritis intestinal metaplasia)could also be employed.Moreover,chronic gastritis has a higher risk of progressing to gastric cancer(GC).In this regard,early diagnosis,treatment,and regular testing could reduce the risk of GC in CAG patients.However,the optimal interval for endoscopic monitoring in CAG patients remains uncertain,and it should ideally be tailored based on individual risk evaluations and shared decision-making processes.Although there have been many reports on CAG,the precise etiology and histopathological features of the disease,as well as the diagnosis of CAG patients,are yet to be fully elucidated.Consequently,this review offers a detailed account of CAG,including its key clinical aspects,aiming to enhance the overall understanding of the disease.

关 键 词：Atrophic gastritis Helicobacter pylori infection Autoimmune gastritis DIAGNOSIS Operative link for gastritis assessment staging Gastric cancer risk 

分 类 号：R573.3[医药卫生—消化系统]