Association between autoimmunity-related disorders and prostate cancer:A Mendelian randomization study  

作　　者：Peixian Chen Yue Wang Zhi Xiong Tianlong Luo Yiming Lai Haitao Zhong Shirong Peng Ruilin Zhuang Kaiwen Li Hai Huang 

机构地区：[1]Department of Urology,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou,Guangdong 510120,China [2]National Institutes for Food and Drug Control,Beijing 102629,China [3]Department of Urology,Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Guangdong Provincial Clinical Research Center for Urological Diseases,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou,Guangdong 510120,China [4]Department of Urology,The Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People's Hospital,Qingyuan,Guangdong 511518,China

出　　处：《Cancer Pathogenesis and Therapy》2024年第4期292-298,共7页癌症发生与治疗（英文）

基　　金：supported by the National Key R&D Plan of China(No.2022YFC3602904);the National Natural Science Foundation of China(No.81974395,No.82173036,and No.82173088);Key R&D Plan of Guangdong Province(No.2023B1111030006 and No.202206010117);the Guangdong Province Natural Science Foundation(No.2022A1515012497and No.2022A1515012383);the Science and Technology Planning Project of Guangdong Province(No.2023B1212060013);Guangdong Provincial Clinical Research Center for Urological Diseases(No.2020B1111170006);the Guangzhou Science and Technology Fund(No.A202201011299);International Science and Technology Cooperation Project Plan of Guangdong Province(No.2021A0505030085);Sun Yat-Sen University Clinical Research 5010 Program(No.2019005);Beijing Bethune Charitable Foundation(No.mnzl202001);Beijing Xisike Clinical Oncology Research Foundation(No.Y-MSDZD2022-0760 and No.Y-tongshu2021/ms-0162);open research funds from the Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People's Hospital。

摘　　要：Background:Although many epidemiological studies and meta-analyses have reported an association between autoimmune disorders and prostate cancer,none has reported a clear correlation or the direction of the association.The purpose of our study was to explore the potential relationship between autoimmunity-related disorders and prostate cancer using Mendelian randomization(MR).Methods:We retrieved literature from PubMed using the keywords“autoimmune disorder”AND“prostate cancer”to find more clues on the correlation between prostate cancer and autoimmunity-related disorder.Based on this literature search,we selected 16 autoimmunity-related disorders that had genome-wide association study(GWAS)data and may be associated with prostate cancer.The inverse variance weighting(IVW)method was applied as our primary analysis for two-sample MR and multivariate MR analysis to estimate the odds ratio(OR)and 95%confidence interval(CI).We further verified the robustness of our conclusions using a series of sensitivity analyses.Results:The autoimmunity-related diseases selected include rheumatoid arthritis,ankylosing spondylitis,coxarthrosis,gonarthrosis,Crohn's disease,ulcerative colitis,irritable bowel syndrome,celiac disease,primary sclerosing cholangitis,asthma,type 1 diabetes,systemic lupus erythematosus,multiple sclerosis,autoimmune hyperthyroidism,psoriatic arthropathies,and polymyalgia rheumatica.The results of inverse variance weighting(IVW suggested that six diseases were associated with the development of prostate cancer.The three diseases that may increase the risk of prostate cancer are rheumatoid arthritis(P=0.001),coxarthrosis(P<0.001),and gonarthrosis(P=0.008).The three possible protective factors against prostate cancer are primary sclerosing cholangitis(P=0.001),autoimmune hyperthyroidism(P=0.011),and psoriatic arthropathies(P=0.001).Horizontal pleiotropy was not observed in the MR-Egger test.Conclusions:Our findings provide predictive genetic evidence for an association between autoimmune disorders and

关 键 词：Prostate cancer Autoimmunity-related diseases Potential relationship Mendelian randomization 

分 类 号：R737.25[医药卫生—肿瘤]