重组人表皮生长因子外用溶液联合重组人粒细胞刺激因子治疗化疗所致口腔黏膜炎的效果  

The Efficacy of Recombinant Human Epidermal Growth FactorTopical Solution in Combination with Recombinant Human GranulocyteStimulating Factor for Chemotherapy-Induced Oral Mucositis

作　　者：刘丹丹 杨磊 窦银慧 LIU Dan-dan;YANG Lei;DOU Yin-hui(Pingdingshan First People's Hospital,Pingdingshan,467000,Henan)

机构地区：[1]平顶山市第一人民医院,河南平顶山467000

出　　处：《黔南民族医专学报》2024年第3期265-268,共4页Journal of Qiannan Medical College for Nationalities

摘　　要：目的:探讨重组人表皮生长因子外用溶液联合重组人粒细胞刺激因子(RHGSF)治疗化疗所致口腔黏膜炎的效果。方法:采用乱数表法将102例老年CHF患者分组;常规组(n=48例)采用重组人表皮生长因子外用溶液治疗,联合组(n=54例)则联合RHGSF辅助治疗;对两组患者的临床疗效、HIF-1α、VEGF、口腔pH值及VAS评分情况进行比较。结果:经28 d治疗后,联合组治疗总有效率高于常规组、血清HIF-1α的平均水平低于常规组、VEGF水平高于常规组、VAS评分低于常规组、pH值低于常规组,各指标组间具显著性差异(P<0.05)。结论:采用重组人表皮生长因子外用溶液联合RHGSF治疗化疗所致口腔黏膜炎的疗效显著,可碱化患者口腔唾液,缓解疼痛,实现抗炎和修复口腔黏膜的作用。Objective:To investigate the efficacy of recombinant human epidermal growth factor topical solution combined with recombinant human granulocyte stimulating factor(RHGSF)in the treatment of chemotherapy-induced oral mucositis.Methods:A total of 102 elderly patients with CHF were randomly divided into two groups using a random number table.The conventional group(n=48)received treatment with recombinant human epidermal growth factor topical solution,while the combination group(n=54)received additional RHGSF as adjuvant therapy.The clinical efficacy,HIF-1αlevels,VEGF levels,oral pH values,and VAS scores were compared between the two groups.Results:After 28 days of treatment,the total effective rate of the combination group was higher than that of the conventional group.The mean serum HIF-1αlevel was lower,VEGF level was higher,VAS score was lower,and pH value was lower in the combination group compared to the conventional group,with statistically significant differences observed in all indicators between the groups(P<0.05).Conclusion:The combined use of recombinant human epidermal growth factor topical solution and RHGSF shows significant efficacy in the treatment of chemotherapy-induced oral mucositis.It can alkalinize oral saliva,alleviate pain,and achieve anti-inflammatory and oral mucosal repair effects.

关 键 词：RHGSF 人粒细胞刺激因子 口腔黏膜炎 VEGF 

分 类 号：R781.5[医药卫生—口腔医学]