miRNA-146a基因多态性与缺血性卒中后抑郁的相关性  

Association between miRNA-146a gene polymorphisms and ischemic post-stroke depression

作　　者：符家武 吴昊 廖志敏 陈婧 李君良 FU Jiawu;WU Hao;LIAO Zhimin;CHEN Jing;LI Junliang(Department of Neurology,Guangdong Medical University Hospi-tal,Zhanjiang 524000,Guangdong,China)

机构地区：[1]广东医科大学附属医院神经内科,广东湛江524000

出　　处：《实用医学杂志》2024年第19期2708-2712,共5页The Journal of Practical Medicine

基　　金：广东省医学科学技术研究基金项目(编号:A2020584);湛江市科技计划项目(编号:2019A01024)。

摘　　要：目的分析miRNA-146a基因多态性与缺血性卒中后抑郁的相关性。方法采用SNaPshot技术对200例缺血性卒中后抑郁患者(病例组)和200例缺血性卒中后非抑郁患者(对照组)的miRNA-146a基因rs2910164位点进行基因型检测,并检测两组外周血miRNA-146a相对表达量。结果相比对照组rs2910164位点的等位基因与基因型频率分布,病例组均差异有统计学意义(G vs.C:P=0.003;GG+CG vs.CC:P=0.012);病例组miRNA-146a相对表达量明显低于对照组(P<0.05);对照组GG+CG基因型的miRNA-146a相对表达量明显低于CC基因型(P<0.05)。结论miRNA-146a基因rs2910164位点与缺血性卒中后抑郁易感性相关,G等位基因可能是缺血性卒中后抑郁发病的因素。Objective To analyze the relationship of miRNA-146a gene polymorphisms and ischemic post-stroke depression(PSD).Methods The SNP rs2910164 in the miRNA-146a gene in 200 ischemic PSD patients(case group)and 200 ischemic non-PSD patients(control group)was analyzed using the SNaPshot technique.The relative expression levels of miRNA-146a in the peripheral blood of two groups were determined.Results The case group showed significantly different allele and genotype frequencies of the SNP rs2910164 as compared with the control group(G vs.C:P=0.003;GG+CG vs.CC:P=0.012).Meanwhile,the case group presented a significantly lower level of miRNA-146a relative expression(P<0.05).Within the control group,additionally,the subgroup of GG+CG genotypes demonstrated a significantly lower level of miRNA-146a relative expression compared with the subgroup of CC genotypes(P<0.05).Conclusion SNP rs2910164 in the miRNA-146a is associated with the susceptibility to ischemic PSD,and G allele may play a role in the ischemic PSD.

关 键 词：miRNA-146a 缺血性卒中后抑郁 基因多态性 相对表达量 

分 类 号：R743.3[医药卫生—神经病学与精神病学]