醋酸泼尼松龙注射液局部封闭治疗OLP的安全性评估  

Safety evaluation of prednisolone acetate injection in local blocking treatment of oral lichen planus

作　　者：秦雨 杨建堂 QIN Yu;YANG Jian-tang(Changsha Stomatological Hospital,Hunan Changsha 410000,China;The Affiliated Stomatological Hospital of Zunyi Medical University,Guizhou Zunyi 563000,China.)

机构地区：[1]长沙市口腔医院,湖南长沙410000 [2]遵义医科大学附属口腔医院,贵州遵义563000

出　　处：《临床口腔医学杂志》2024年第9期533-537,共5页Journal of Clinical Stomatology

基　　金：国家自然科学基金项目(81960202);黔科合(贵州省科技厅联合基金)项目(LH字[2015]7563号)。

摘　　要：目的:检测口腔扁平苔藓(oral lichen planus,OLP)患者醋酸泼尼松龙注射液局部封闭治疗前后空腹血糖、血压、血常规、血脂、肝肾功及电解质,评估醋酸泼尼松龙注射液局部封闭治疗OLP的安全性。方法:OLP纳入的患者予醋酸泼尼松龙注射液局部封闭:醋酸泼尼松龙注射液与2%盐酸利多卡因注射液1:1混合共3 mL(约含醋酸泼尼松龙注射液0.0375 g)分5~8个注射点全部注射入OLP充血糜烂面周围黏膜下。治疗前与治疗后连续7 d记录患者空腹血糖、血压,并于第7天查血常规、血脂、肝功能、肾功能及电解质,同时记录视觉模拟评分(visual analogue scale,VAS)和网纹-糜烂-溃疡评分量表(reticular erosive and ulcerative lesion,REU)评分。结果:醋酸泼尼松龙注射液局部封闭治疗后OLP患者的空腹血糖较治疗前均有升高,但仅治疗后第1天空腹血糖较治疗前升高有统计学意义(P<0.05)。治疗后血压、血常规、肝肾功、电解质结果较治疗前比较血压无明显波动,且差异没有统计学意义(P>0.05);治疗后血脂中的高密度脂蛋白较治疗前升高,且具有统计学意义(P<0.05)。患者VAS和REU评分结果显示疼痛程度以及病损范围治疗后较治疗前明显降低,且具有统计学意义(P<0.01)。结论:在合理控制剂量的前提下,醋酸泼尼松龙注射液局部封闭治疗OLP有效,且对血压、血常规、肝肾功、电解质无明显影响,但患者治疗后第1天空腹血糖和第7天高密度脂蛋白有不同程度的升高。Objective:To detect fasting blood glucose,blood pressure,blood routine,blood lipid,liver and kidney function and electrolyte in patients with oral lichen planus(OLP)before and after local blocking treatment with prednisolone acetate injection,and to evaluate the safety of local blocking treatment with prednisolone acetate injection for OLP.Methods:According to the inclusion criteria and exclusion criteria,the newly diagnosed OLP patients were collected.The patients were partially blocked with prednisolone acetate injection:3 mL(about 0.0375 g of prednisolone acetate injection)was mixed with 2%lidocaine hydrochloride injection in 1:1,and all of them were injected into the submucosa around the hyperemic and septic surface of OLP at 5~8 injection points.Fasting blood sugar,blood pressure and heart rate were recorded before treatment and for 7 consecutive days after treatment,and blood routine,blood lipid,liver function,renal function and electrolyte were checked before treatment and on the seventh day,and visual analogue scale(VAS)and reticular erosive and ulcerative lesion(REU)scores were also recorded.Results:The fasting blood glucose of OLP patients after local blocking treatment with prednisolone acetate injection was higher than that before treatment,but only on the first day after treatment was the fasting blood glucose higher than that before treatment(P<0.05).After treatment,the blood pressure,blood routine,liver and kidney function and electrolyte results showed no obvious fluctuation compared with those before treatment,and the results were not statistically significant(P>0.05).After treatment,the high-density lipoprotein(HDL)in patients'blood lipid was higher than that before treatment,and it was statistically significant(P<0.05).The results of VAS and REU scores showed that the degree of pain and the scope of lesion were significantly lower after treatment than before treatment(P<0.01).Conclusion:Under the premise of reasonable dose control,prednisolone acetate injection was effective in the local occlus

关 键 词：局部封闭 糖皮质激素 口腔扁平苔藓 

分 类 号：R781.5[医药卫生—口腔医学]