多西紫杉醇联合卡培他滨治疗转移性乳腺癌的效果分析  

Analysis of the Effect of Docetaxel Combined with Capecitabine in the Treatment of Metastatic Breast Cancer

作　　者：刘云军[1] 何志江[1] 温坚[1] 杨子恒 Liu Yunjun;He Zhijiang;Wen Jian;Yang Ziheng(Second Department of Oncology,Maoming People's Hospital,Maoming 525000,Guangdong Province,China)

机构地区：[1]茂名市人民医院肿瘤二科,广东茂名525000

出　　处：《中国社区医师》2024年第26期31-33,共3页Chinese Community Doctors

摘　　要：目的:探讨多西紫杉醇联合卡培他滨治疗转移性乳腺癌的临床效果。方法:将2020年1—12月茂名市人民医院收治的72例转移性乳腺癌患者随机分为两组,各36例。对照组使用多西紫杉醇联合卡铂治疗,观察组使用多西紫杉醇联合卡培他滨治疗。对比两组近期疗效、毒副反应发生情况、Karnofsky功能状态评分(KPS)、生存指标、肿瘤标志物水平。结果:观察组治疗总有效率、疾病控制率、KPS评分均高于对照组,毒副反应发生率及癌胚抗原、糖类抗原199、糖类抗原153、糖类抗原125水平低于对照组(P<0.05)。两组无进展生存时间、中位生存时间、1年生存率、2年生存率比较,差异无统计学意义(P>0.05)。结论:多西紫杉醇联合卡培他滨治疗转移性乳腺癌的近期疗效较好,患者毒副反应发生率低,肿瘤标志物水平下降显著,健康状况良好,但远期效果有限。Objective:To investigate the clinical effect of docetaxel combined with capecitabine in the treatment of metastatic breast cancer.Methods:Seventy-two patients with metastatic breast cancer admitted to Maoming People's Hospital from January to December 2020 were randomly divided into two groups of thirty-six cases each.The control group was treated with docetaxel combined with carboplatin,and the observation group was treated with docetaxel combined with capecitabine.The two groups were compared in terms of recent therapeutic efficacy,occurrence of toxic side effects,Karnofsky functional status score(KPS),survival indicators,and tumor marker levels.Results:The total effective rate of treatment,disease control rate,and KPS score of the observation group were higher than those of the control group,and the incidence of toxic side effects and the levels of carcinoembryonic antigen,glycoantigen 199,glycoantigen 153,and glycoantigen 125 were lower than those of the control group(P<0.05);comparison of progression-free survival time,median survival time,1-year survival rate,and 2-year survival rate between the two groups showed no statistically significant difference(P>0.05).Conclusion:The near-term efficacy of docetaxel combined with capecitabine in the treatment of metastatic breast cancer is better,with a low incidence of toxic side effects in patients,a significant decrease in the level of tumor markers,and a good health status,but the long-term effect is limited.

关 键 词：转移性乳腺癌 多西紫杉醇 卡培他滨 卡铂 

分 类 号：R737.9[医药卫生—肿瘤]