低级别胶质瘤异柠檬酸脱氢酶-1基因分型与磁共振表观弥散系数、血管内皮生长因子表达的关系  

Analysis of the relationship between IDH-1 typing and magnetic resonance apparent diffusion coefficient,VEGF expression in low-grade gliomas

作　　者：杜山别克·克孜 DUSHANBIEKE·Kezi(Author Affiliation:Department of Neurosurgery,Cancer Hospital Affiliated to Xinjiang Medical University,Urumqi,Xinjiang Uygur Autonomous Region 830011,China)

机构地区：[1]新疆医科大学附属肿瘤医院神经外科,新疆维吾尔自治区乌鲁木齐830011

出　　处：《安徽医药》2024年第11期2187-2191,共5页Anhui Medical and Pharmaceutical Journal

基　　金：新疆维吾尔自治区自然科学基金资助项目(2020D01C202)。

摘　　要：目的探讨低级别胶质瘤病人异柠檬酸脱氢酶-1(IDH-1)基因分型与磁共振表观弥散系数(ADC)、血管内皮生长因子(VEGF)表达的关系。方法纳入新疆医科大学附属肿瘤医院2021年6月至2023年5月收治的低级别脑胶质瘤病人52例开展回顾性研究,病人术前均接受磁共振弥散加权成像检查,经手术病理与WHO中枢神经系统肿瘤分级标准证实为低级别脑胶质瘤,根据IDH-1分型结果分成突变型组29例、野生型组23例。比较两组最小ADC值(ADC_(min))、平均ADC值(ADC_(mean))、最小相对ADC值(rADC_(min))、平均相对ADC值(rADC_(mean))。绘制受试者操作特征曲线(ROC曲线)分析ADC值对IDH-1分型的鉴别价值。分析病人IDH-1分型与VEGF表达的关系,比较不同VEGF表达病人的ADC值。结果突变型组ADC_(min)、ADC_(mean)、rADC_(min)、rADC_(mean)较野生型组增高(P<0.05)。ADC_(min)、ADC_(mean)、rADC_(min)、rADC_(mean)鉴别IDH-1分型的曲线下面积(AUC)分别为0.77(灵敏度75.86%,特异度73.91%)、0.79(灵敏度82.76%,特异度78.26%)、0.76(灵敏度79.31%,特异度78.26%)、0.77(灵敏度79.31%,特异度82.61%)。突变型组VEGF阳性率为13.79%,低于野生型组的47.83%(P<0.05)。VEGF阴性/弱阳性组ADC_(min)、ADC_(mean)、rADC_(min)、rADC_(mean)高于阳性组(P<0.05)。结论低级别脑胶质瘤IDH-1突变者的ADC_(min)、ADC_(mean)、rADC_(min)、rADC_(mean)相对高,ADC参数对其IDH-1分型具有鉴别价值,且IDH-1分型与VEGF表达相关。Objective To investigate the relationship between isocitrate dehydrogenase 1(IDH-1)genotyping and the expression of magnetic resonance apparent diffusion coefficient(ADC)and vascular endothelial growth factor(VEGF)in low-grade glioma patients.Methods A retrospective study was carried out on 52 patients with low-grade glioma admitted to Cancer Hospital Affiliated to Xinjiang Medical University from June 2021 to May 2023.All patients were examined by diffusion-weighted magnetic resonance imaging before surgery,and were confirmed as low-grade glioma by surgical pathology and WHO central nervous system tumor grading criteria.According to the results of IDH-1,they were divided into mutant group(n=29)and wild type group(n=23).The minimum ADC value(ADC_(min)),average ADC value(ADC_(mean)),minimum relative ADC value(rADC_(min))and average relative ADC value(rADC_(mean))of the two groups were compared.Receiver operating characteristic(ROC)curve was drawn to analyze the value of ADC value in differentiating IDH-1 typing.The relationship between IDH-1 type and VEGF expression was analyzed,and ADC values of patients with different VEGF expression were compared.Results ADC_(min),ADC_(mean),rADC_(min) and rADC_(mean) in mutant group were higher than those in wild type group(P<0.05).The area under the curve(AUC)of ADC_(min),ADC_(mean),rADC_(min) and rADC_(mean) for identification of IDH-1 typing were 0.77(sensitivity 75.86%,specificity 73.91%),0.79(sensitivity 82.76%,specificity 73.91%),0.76(sensitivity 79.31%,specificity 78.26%)and 0.77(sensitivity 79.31%,specificity 82.61%),respectively.The positive rate of VEGF in mutant group was 13.79%,lower than 47.83%in wild type group(P<0.05).ADC_(min),ADC_(mean),rADC_(min) and rADC_(mean) in negative/weak positive VEGF group were higher than those in positive group(P<0.05).Conclusion ADC_(min),ADC_(mean),rADC_(min) and rADC_(mean) are relatively high in low-grade glioma with IDH-1 mutation,and ADC parameters are valuable in differentiating IDH-1 classification,and IDH-1 classification

关 键 词：神经胶质瘤 肿瘤分级 磁共振表观弥散系数 异柠檬酸脱氢酶-1 突变型 野生型 

分 类 号：R739.41[医药卫生—肿瘤] R445.2[医药卫生—临床医学]