银杏达莫联合阿司匹林对急性脑梗死患者脑血流动力学指标、血清炎性细胞因子的影响  

Effect of Ginkgo Damol Combined with Aspirin on Cerebral Hemodynamic Index and Serum Inflammatory Cytokines in Patients with Acute Cerebral Infarction

作　　者：张梦琳 豆冬霞 闫宏杰 闫秋分 ZHANG Meng-lin;DOU Dong-xia;YAN Hong-jie;YAN Qiu-fen(Department of Neurology,Boai County People's Hospital,Boai,Henan,454450,China)

机构地区：[1]河南省博爱县人民医院神经内科,河南博爱454450

出　　处：《中国血液流变学杂志》2024年第2期222-225,240,共5页Chinese Journal of Hemorheology

摘　　要：目的研究银杏达莫联合阿司匹林对急性脑梗死患者脑血流动力学指标、血清炎性细胞因子的影响。方法以2021年8月—2023年8月博爱县人民医院收治的80例急性脑梗死患者为研究对象,根据治疗方案不同将患者分为对照组、联合组,每组各40例。对照组采用阿司匹林治疗,联合组采用银杏达莫联合阿司匹林治疗。比较两组临床疗效、治疗前后NIHSS评分、简易智力状态检查量表(MMSE)评分、日常生活活动能力量表(ADL)评分、脑血流动力学指标[平均血流速度(Vmean)、收缩期峰值血流速度(Vmax)、搏动指数(PI)]、血清炎性细胞因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、CXC趋化因子配体1(CXCL1)、CC趋化因子配体4(CCL4)]、不良反应总发生率。结果联合组总有效率92.50%高于对照组75.00%(P<0.05);治疗后联合组NIHSS评分、PI值低于对照组,MMSE评分、ADL评分、Vmean、Vmax值高于对照组(P<0.05);治疗后联合组血清hs-CRP、TNF-α、CXCL1、CCL4水平降低幅度大于对照组(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论银杏达莫联合阿司匹林治疗ACI患者临床疗效确切,可改善患者神经功能、认知功能及脑血流动力学,有助于减轻患者临床症状。Objective To study the effect of Ginkgo Damol and Aspirin on cerebral hemodynamic indexes and serum inflammatory cytokines in patients with acute cerebral infarction.Methods 80 patients with acute cerebral infarction admitted to Boai County People's Hospital from August 2021 to August 2023 were selected as the study objects.According to different treatment regiments,the patients were divided into control group and combination group,with 40 cases in each group.The control group was treated with Aspirin,and the combination group was treated with Ginkgo Damol combined with Aspirin to compare the clinical efficacy of the two groups,as well as NIHSS score,MMSE score,ADL score,cerebral hemodynamic indexes[mean blood flow velocity(Vmean),peak systolic blood velocity(Vmax),pulse index(PI)]and serum inflammatory cytokines[hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),CXC chemokine ligand 1(CXCL1),CC chemokine ligand 4(CCL4)],and overall incidence of adverse reactions before and after treatment.Results The total effective rate of the combination group was 92.50%higher than that of the control group 75.00%(P<0.05).After treatment,NIHSS score and PI value of combination group were lower than those of control group,MMSE score,ADL score,Vmean and Vmax values were higher than those of control group(P<0.05).After treatment,the levels of serum hs-CRP,TNF-α,CXCL1 and CCL4 in combination group decreased more than those in control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Ginkgo Damol combined with Aspirin in the treatment of ACI patients has definite clinical effect,which can improve the neurological function,cognitive function and cerebral hemodynamics,and help alleviate the clinical symptoms of patients.

关 键 词：银杏达莫 阿司匹林 急性脑梗死 疗效 

分 类 号：R743.3[医药卫生—神经病学与精神病学]