MEIS1表达对胃癌根治术后患者生存期的影响及其在预后评估中的价值  

Effect of MEIS1 expression on survival in patients after radical gastrectomy and its value in prognostic evaluation

作　　者：易嘉欣 张扬雨 付颖利 潘禹辰[1] 韩永杰 姜晶[1] 吴燕华 YI Jiaxin;ZHANG Yangyu;FU Yingli;PAN Yuchen;HAN Yongjie;JIANG Jing;WU Yanhua(Department of Clinical Epidemiology,First Hospital,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院临床流行病学研究室,吉林长春130021

出　　处：《吉林大学学报（医学版）》2024年第5期1358-1364,共7页Journal of Jilin University：Medicine Edition

基　　金：国家自然科学基金项目(82373664);吉林省卫健委卫生健康科技能力提升计划项目(2023LC001)。

摘　　要：目的:探讨不同表达水平骨髓嗜病毒整合位点1 (MEIS1)胃癌患者的术后生存情况,分析MEIS1表达在胃癌患者预后评估中的预测价值。方法:在胃癌生存队列中选取215例行胃癌根治术的患者。免疫组织化学染色法检测胃癌和癌旁正常组织中MEIS1表达水平。采用χ^(2)检验或Fisher确切概率法分析MEIS1表达水平与患者临床病理特征的关系;采用Kaplan-Meier法绘制生存曲线,采用Log-rank检验比较MEIS1高表达组和MEIS1低表达组胃癌患者生存差异;采用多因素Cox比例风险回归模型计算风险比(HR)及其95%置信区间(CI),评价MEIS1表达水平与胃癌患者生存的关系。结结果果:免疫组织化学染色,MEIS1在胃癌组织中表达水平降低;单因素分析,MEIS1高表达患者比MEIS1低表达患者总生存期长(P=0.049),预后更好;多因素Cox比例风险回归分析,MEIS1低表达和TNM分期高是胃癌患者预后的独立危险因素(HR=1.577, 95%CI:1.011~2.460, P=0.045;HR=2.709, 95%CI:1.708~4.297, P<0.001)。结结论论:MEIS1低表达胃癌患者术后总生存期短,MEIS1有望成为胃癌根治术后患者预后评估的生物标志物。Objective:To discuss the postoperative survival of the gastric cancer patients with different expression levels of myeloid ecotropic viral integration site 1(MEIS1),and to analyze the predictive value of MEIS1 expression in the prognosis evaluation of gastric cancer.Methods:In a gastric cancer survival cohort,215 patients who underwent radical gastrectomy were selected.Immunohistochemical staining was used to detect the expression levels of MEIS1 in both gastric cancer and adjacent normal tissues.The relationship between expression level of MEIS1 and the clinicopathological characteristics of the patients were analyzed byχ^(2) test or Fisher’s exact probability method;survival curves were plotted by Kaplan-Meier method;the differences in survival of the patients between MEIS1 high expression group and MEIS1 low expression group were compared by Log-rank test;multivariate Cox proportional hazards regression model was used to calculate the hazard ratios(HR)and 95%confidence intervals(CI)to assess the relationship between MEIS1 expression level and the survival of the gastric cancer patients.Results:The immunohistochemical staining result showed that the expression level of MEIS1 in gastric cancer tissue was decreased.The univariate analysis results showed that the patients with high MEIS1 expression had a longer overall survival than those with low expression(P=0.049),and had a better prognosis.The multivariate Cox proprotional hazards regression analysis results showed that the low MEIS1 expression and high TNM stage were the independent risk factors for poor prognosis of the patients with gastric cancer(HR=1.577,95%CI:1.011-2.460,P=0.045;HR=2.709,95%CI:1.708-4.297,P<0.001).Conclusion:The gastric cancer patients with low expression of MEIS1 have a shorter postoperative overall survival;MEIS1 is a promising biomarker for prognosis assessment of the patients after radical gastrectomy.

关 键 词：骨髓嗜病毒整合位点1 胃肿瘤 预后 生物标志物 胃癌根治术 

分 类 号：R735.2[医药卫生—肿瘤]