^(18)F-FDG PET/CT在胃癌诊断和预后评估中的应用  

Application of ^(18)F-FDG PET/CT in the diagnosis and prognosis assessment of gastric cancer

作　　者：魏利娟 丁恩慈[1] 芮忠颖 沈婕[1] 范国聚 Wei Lijuan;Ding Enci;Rui Zhongying;Shen Jie;Fan Guoju(Department of Nuclear Medicine,Tianjin First Central Hospital,Tianjin 300192,China;Department of Vascular Surgery,the Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津市第一中心医院核医学科,天津300192 [2]天津医科大学第二医院血管外科,天津300211

出　　处：《中华解剖与临床杂志》2024年第9期637-642,共6页Chinese Journal of Anatomy and Clinics

基　　金：天津市卫生健康委员会科技项目(TJWJ2021MS013)。

摘　　要：目的总结^(18)F-氟代脱氧葡萄糖(^(18)F-FDG)正电子发射体层摄影(PET)/CT在胃癌诊断和预后评估中的应用。方法在中国知网、万方数据、中华医学期刊全文数据库和PubMed等数据库中, 以"胃癌""^(18)F-氟代脱氧葡萄糖""PET/CT""诊断分期""预后评估"以及"gastric cancer""^(18)F-FDG""PET/CT""diagnosis stage""prognosis assessment"等为中、英文关键词, 检索2023年12月前公开发表的^(18)F-FDG PET/CT在胃癌诊断、分期、预后评估及复发检测中应用的相关文献共378篇, 剔除内容不符、无法获取原文、重复性研究及低质量文献, 最终纳入39篇文献进行总结和分析。结果 ^(18)F-FDG PET/CT显像可以直观显示胃癌原发灶部位、形态、大小, 在区域淋巴结转移尤其隐匿性淋巴结转移方面较其他影像检查具有明显优势, 在远处转移方面显示直观全面、不易漏诊, 并且在胃癌与胃原发性淋巴瘤鉴别诊断中具有重要价值。^(18)F-FDG PET/CT可提供肿瘤多种代谢参数、反映FDG摄取定量信息, 在胃癌的诊断与鉴别诊断、分期、疗效评价、预后评估、复发检测方面发挥了极大优势, 改变了部分患者的治疗方案。但^(18)F-FDG PET/CT对少数特殊病理类型胃癌(如胃印戒细胞癌、黏液腺癌)诊断灵敏度较低;新型显像剂的研发旨在弥补其不足, 目前研究较多的为68Ga标记的成纤维细胞激活蛋白抑制剂。结论 ^(18)F-FDG PET/CT在胃癌诊断及鉴别诊断、分期、预后评估及复发检测中发挥重要作用, 但^(18)F-FDG PET/CT诊断少数特殊病理类型胃癌仍有不足。Objective To summarize the research progress on the application of ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)in the diagnosis and prognosis assessment of gastric cancer.Methods A searched in Chinese and English databases,such as CNKI,Wanfang,Chinese Medical journal full text database,and PubMed,using"胃癌""^(18)F-氟代脱氧葡萄糖""PET/CT""诊断分期""预后评估""gastric cancer""^(18)F-FDG""PET/CT""diagnosis stage""prognosis assessment"as Chinese and English keywords yielded 378 articles on the application of ^(18)F-FDG PET/CT in the diagnosis,staging,prognosis evaluation,and recurrence detection of gastric cancer published before December 2023.A total of 39 articles were summarized and analyzed through elimination of the papers that did not accord with the content of this work,articles with unavailable full texts,duplicates,and low-quality papers.Results ^(18)F-FDG PET/CT imaging can visually display the location,shape,and size of the primary lesion of gastric cancer.This procedures exhibits evident advantages over other imaging examinations in regional lymph node metastasis,especially occult lymph node metastasis.This method is intuitive and comprehensive in the detection of distant metastasis,hardly misses diagnosis,and has value in the differential diagnosis between gastric cancer and primary gastric lymphoma.^(18)F-FDG PET/CT can provide multiple metabolic tumor parameters and reflect quantitative information on FDG uptake.This method has shown a great advantage in efficacy evaluation,prognosis evaluation,and recurrence detection,which contribute to alterations in the treatment plan of some patients.^(18)F-FDG PET/CT reduces the diagnostic sensitivity in a few special pathological types of gastric cancer,such as signet-ring cell carcinoma and mucinous adenocarcinoma.The research and development of new imaging agents are aimed at compensating for its deficiency.At present,the most studied imaging agents include 68Ga-labeled fibroblast activating pro

关 键 词：胃肿瘤 正电子发射体层摄影/计算机体层成像 ^(18)F-氟代脱氧葡萄糖 诊断分期 预后评估 

分 类 号：R735.2[医药卫生—肿瘤] R730.44[医药卫生—临床医学]