神经轴突导向分子Slit3的相关研究进展  

Research progression of slit guidance ligand 3

作　　者：蒋欢 李姣清 徐浩森 兰金意 杨单植 张婷[1] 刘沛敏 吴丹凤 白晓燕[1,2,3] Jiang Huan;Li Jiaoqing;Xu Haosen;Lan Jinyi;Yang Shanzhi;Zhang Ting;Liu Peimin;Wu Danfeng;Bai Xiaoyan(Department of Nephrology,Guangdong Provincial People s Hospital,Southern Medical University/Guangdong Academy of Medical Science,Guangzhou 519041,Guangdong,China;Department of Nephrology,Guangdong Cardiovascular Institute,Guangdong Academy of Medical Sciences,Guangzhou 519041,Guangdong,China;Department of Nephrology,Guangdong Medical University,Zhanjiang 524023,Guangdong,China)

机构地区：[1]南方医科大学附属广东省人民医院/广东省医学科学院肾内科,广州510080 [2]广东省心血管病研究所/广东省医学科学院肾内科,广州510080 [3]广东医科大学肾内科,广东湛江524023

出　　处：《首都医科大学学报》2024年第5期917-922,共6页Journal of Capital Medical University

基　　金：国家自然科学基金项目(81873616,8247034859)。

摘　　要：神经轴突导向分子家族(slit guidance ligand,Slit)是一类高度保守的分泌型糖蛋白,与其单次跨膜受体(roundabout guidance receptor,Robo)相互作用。目前,已经在人类发现3个Slit基因(Slit1-3)和4个Robo基因(Robo1-4)。Slit3具有广泛的生物学功能,如细胞迁移、骨形成、血管生成和肿瘤发生。Slit3在不同临床疾病中的致病作用及机制尚未完全阐明,值得深入研究探索。通过研究Slit3在不同疾病中的作用和发病机制,将为探索其生物学作用及发病机制,研发靶向治疗方案提供理论依据和新思路。本文综述Slit3在各类疾病中的研究进展,并阐述其在相关疾病中的作用及可能机制。Slit guidance ligand(Slit)is a family of highly conserved secreted glycoproteins that interact with their roundabout guidance receptor(Robo).At present,three Slit genes(Slit 1-3)and fou r Robo genes(Robo 1-4)have been identified in mammals.Studies have shown that Slit3 has a wide range of biological functions,such as cell migration,bone formation,angiogenesis,and tumorigenesis.At the same time,the mechanisms of Slit3-involved diseases have been investigated,though the pathogenesis of Slit3 is not fully understood.Through studying the pathogenesis of Slit3,we could better explore the pathogenic targets for disease progression and specific treatment.This review summarized the research progress of Slit3 in various diseases,and expounded its role and possible mechanism in related diseases.

关 键 词：Slit3 发病机制 研究进展 

分 类 号：R363[医药卫生—病理学]