乳酸代谢在动脉粥样硬化中的作用研究进展  

Research progress on the role of lactate metabolism in atherosclerosis

作　　者：张蕴 张弟源 朱欣婷 梁星 ZHANG Yun;ZHANG Diyuan;ZHU Xinting;LIANG Xing(Chongqing Medical University,Chongqing 400016,China;the Second Affliated Hospital of Chongqing Medical University,Chongqing 400000,China)

机构地区：[1]重庆医科大学,重庆市400016 [2]重庆医科大学附属第二医院,重庆市400000

出　　处：《中国动脉硬化杂志》2024年第10期907-915,共9页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(82100464);重庆市自然科学基金项目(cstc2020jcyj-msxmX0247)。

摘　　要：动脉粥样硬化是一种由脂质驱动的慢性炎症性疾病,以大中型动脉内膜下粥样硬化性斑块形成为主要特征,是导致缺血性心脏病和中风的主要原因。近期研究发现,在动脉粥样硬化的进展过程中,动脉粥样硬化斑块内细胞糖酵解水平增加,导致乳酸过量生成和排出以及细胞外环境酸化,可能通过多种机制进一步影响动脉粥样硬化的发展。该文对乳酸代谢在动脉粥样硬化中的作用研究进展进行综述,旨在为动脉粥样硬化的防治提供新的治疗靶点和方向。Atherosclerosis is a lipid-driven chronic inflammatory disease that typically forms plaques in large and medium-sized arteries and is a major cause of ischemic heart disease and stroke.Recent studies have found that during the progression of atherosclerosis,the level of cellular glycolysis in plaques increases,leading to excessive production and excretion of lactate and acidification of the extracellular environment,which may further affect the development of atherosclerosis through multiple mechanisms.This article reviews the research progress on the role of lactate metabolism in atherosclerosis,which may provide new therapeutic targets and directions for the prevention and treatment of atherosclerosis.

关 键 词：动脉粥样硬化 乳酸代谢 能量代谢 

分 类 号：R363[医药卫生—病理学] R5[医药卫生—基础医学]