盐酸罂粟碱注射液联合阿替普酶静脉溶栓对于发病<4.5 h急性脑梗死治疗的近期效果及安全性研究  

Efficacy and safety of papaverine hydrochloride injection combined with Alteplase intravenous thrombolysis in the treatment of acute cerebral infarction<4.5 h

作　　者：仵赵瑶 段菁 刘定斌 Wu Zhao-yao;Duan Jing;Liu Ding-bin(Department of Neurology,The First Affiliated Hospital of Nanyang Medical College,Nanyang 473007,Henan,China)

机构地区：[1]南阳医学高等专科学校第一附属医院神经内科,河南南阳473007

出　　处：《四川生理科学杂志》2024年第10期2195-2197,共3页

摘　　要：目的:分析盐酸罂粟碱注射液联合阿替普酶动脉溶栓治疗发病<4.5 h急性脑梗死的治疗效果。方法:回顾性收集2022年8月-2023年8月期间本院收治的进行手术治疗的81例急性脑梗死患者的临床资料。按照治疗方案的不同,将患者分为对照组(注射盐酸罂粟碱,38例)和观察组(盐酸罂粟碱注射液联合阿替普酶治疗,43例)。分析对比两组的神经功能[神经功能缺损量表(NIHSS)]、临床疗效[临床疗效总评量表(CGI)]、生活自理能力(改良Barthel指数量表)以及安全性。结果:两组治疗后的NHISS评分均比治疗前显著降低,且观察组的NHISS评分的下降幅度显著大于对照组(P<0.05)。两组治疗后的SI评分均显著降低,GI、EI评分均显著升高,且观察组的各项评分的变化幅度均显著大于对照组(P<0.05)。两组治疗后的Barthel评分均显著上升,且观察组的Barthel评分显著高于对照组(P<0.05)。两组的不良反应发生率无显著差异(P>0.05)。结论:盐酸罂粟碱注射液联合阿替普酶动脉溶栓治疗发病时间<4.5 h的急性脑梗死患者,能改善患者的神经功能,提高临床疗效和生活自理能力,且安全性较高。Objective:To analyze the therapeutic effect of papaverine hydrochloride injection combined with alteplase arterial thrombolysis on acute cerebral infarction<4.5 hours.Methods:The clinical data of 81 patients with acute cerebral infarction who underwent surgical treatment in our hospital from August 2022 to August 2023 were retrospectively collected.According to different treatment plans,the patients were divided into control group(38 cases)and observation group(43 cases).The neurological function(NIHSS),clinical efficacy(CGI),self-care ability(modified Barthel Index)and safety of the two groups were analyzed and compared.Results:The NHISS score of both groups after treatment was significantly lower than that before treatment,and the NHISS score of the observation group was significantly greater than that of the control group(P<0.05).After treatment,SI scores of both groups were significantly decreased,GI and EI scores were significantly increased,and the changes of scores in the observation group were significantly greater than those in the control group(P<0.05).After treatment,the Barthel score of both groups was significantly increased,and the Barthel score of the observation group was significantly higher than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Papaverine hydrochloride injection combined with alteplase arterial thrombolysis in the treatment of acute cerebral infarction patients with onset time<4.5 hours can improve the neurological function of patients,improve clinical efficacy and self-care ability,and have high safety.

关 键 词：盐酸罂粟碱注射液 阿替普酶 溶栓治疗 急性脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]