雷贝拉唑、奥美拉唑治疗Hp阳性消化性溃疡伴出血的临床应用对比  

Comparison of the clinical application of rabeprazole and omeprazole in the treatment of Hp positive peptic ulcer with bleeding

作　　者：于宏环 耿同磊 刘艳红 Yu Hong-huan;Geng Tong-lei;Liu Yan-hong(Department of Gastroenterology,Xunxian People's Hospital,Hebi 456250,Henan,China)

机构地区：[1]浚县人民医院消化内科,河南鹤壁456250

出　　处：《四川生理科学杂志》2024年第10期2306-2308,共3页

摘　　要：目的:对比分析雷贝拉唑、奥美拉唑治疗Hp阳性消化性溃疡伴出血的临床应用效果。方法:回顾性收集2022年2月至2023年8月间本院接治的112例Hp阳性消化性溃疡伴出血患者的临床资料。常规用药一致,根据治疗药物的不同,将患者分为雷贝拉唑组(雷贝拉唑治疗,n=57)和奥美拉唑组(奥美拉唑治疗,n=55)。治疗8 w后对比两组临床疗效、临床症状、心理卫生状态及Hp根除率。结果:治疗后,雷贝拉唑组治疗的总有效率显著高于奥美拉唑组(89.09%)(P<0.05);治疗后,雷贝拉唑组的Hp根除率显著高于奥美拉唑组(P<0.05);雷贝拉唑组的躯体、焦虑、抑郁、人际敏感等9项症状评分均显著低于奥美拉唑(P<0.05);雷贝拉唑组治疗后的腹胀、腹痛缓解率均显著高于奥美拉唑组;嗳气次数、剩余溃疡面积均显著低于奥美拉唑组(P<0.05)。结论:与奥美拉唑比较,雷贝拉唑治疗Hp阳性消化性溃疡伴出血患者临床有效率更高,更有利于改善患者临床症状及心理卫生状态,提高Hp根除率。Objective:To compare and analyze the clinical effects of rabeprazole and omeprazole in the treatment of Hp positive peptic ulcer with bleeding.Methods:The clinical data of 112 HP-positive peptic ulcer patients with bleeding treated in our hospital from February 2022 to August 2023 were retrospectively collected.Conventional drugs,according to different treatment,the patients can be divided into rabeprazole azole groups(rabeprazole azole treatment,n=57)and omeprazole group(omeprazole treatment,n=55).8 weeks after treatment compared two groups of clinical curative effect,clinical symptoms,the psychological health status and Hp eradication rate.Results:After treatment,the overall effective rate of treatment in the rabeprazole group was significantly higher than that in the omeprazole group(89.09%)(P<0.05);after treatment,the Hp eradication rate in the rabeprazole group was significantly higher than that in the omeprazole group(P<0.05);The nine symptom scores for somatic,anxiety,depression,and interpersonal sensitivity were significantly lower in the rabeprazole group than in the omeprazole group(p<0.05);The rate of relief of abdominal distension and abdominal pain after treatment was significantly higher in the rabeprazole group than in the omeprazole group;the number of belches and the area of remaining ulcers were significantly lower than in the omeprazole group(P<0.05).Conclusion:Compared with omeprazole,rabeprazole is more clinically effective in treating patients with Hp-positive peptic ulcer with bleeding,more conducive to improving patients'clinical symptoms and mental health status,and improving the Hp eradication rate.

关 键 词：雷贝拉唑 奥美拉唑 幽门螺杆菌阳性 消化性溃疡伴出血 临床疗效 

分 类 号：R573[医药卫生—消化系统]