双酚类化合物促进乳腺癌转移的研究进展  

Advances Research of Metastasis on Bisphenols Promoting Breast Cancer

作　　者：刘金咪 王海萍 侯晓莹 刘钰晨 LIU Jinmi;WANG Haiping;HOU Xiaoying;LIU Yuchen(School of Medicine,Jianghan University,Wuhan 430056,Hubei,China)

机构地区：[1]江汉大学医学部,湖北武汉430056

出　　处：《江汉大学学报（自然科学版）》2024年第5期79-87,共9页Journal of Jianghan University：Natural Science Edition

基　　金：湖北省教育厅科学研究计划项目(B2019232)。

摘　　要：双酚类化合物(bisphenols,BPs)是最常见的环境内分泌干扰物,且在环境中的含量不断增加。它们通过消化道、呼吸道和皮肤接触途径进入机体,对多个系统均能产生负面影响。乳腺癌是全球女性最常见的恶性肿瘤,流行病学和临床数据表明激素和内分泌干扰物在乳腺癌的发生和发展中发挥重要作用。BPs的长期低剂量暴露还促进乳腺癌的发生发展与转移。介绍了BPs促进乳腺癌转移的研究进展及其潜在作用机制,从环境污染物的角度为理解乳腺癌的转移提供新的思路。Bisphenols(BPs)are the most common environmental endocrine disruptors,and their concentration is still increasing in the environment.Through the digestive system,respiratory system,and dermal contact,BPs enter the human body and then induce negative health effects.Breast cancer is the most common malignant tumor in women worldwide.Epidemiological and clinical data suggest that hormones,as well as endocrine disruptors,play important roles in the development and progression of breast cancer.Long-time lowdose exposure to bisphenols also promotes the development and metastasis of breast cancer.This paper described the research progress and the underlying mechanisms of BPs on promoting breast cancer metastasis,providing new thoughts on understanding breast cancer metastasis from the perspective of environmental pollutants.

关 键 词：双酚类化合物 乳腺癌 转移 分子机制 

分 类 号：R737.902[医药卫生—肿瘤]