斑马鱼在药理毒理研究中的应用进展  

Progress in the application of zebrafish in pharmacological and toxicological research

作　　者：李玉姣 郭健敏 黄远铿 杨威 LI Yu-jiao;GUO Jian-min;HUANG Yuan-keng;YANG Wei(Guangzhou Bay Area Institute of Biomedicine,Guangdong Lewwin Pharmaceutical Research Institute Co.,Ltd.,Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research,TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine,Guangdong Engineering Research Center for Innovative Drug Evaluation and Research,Guangzhou 510990)

机构地区：[1]广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价研究企业重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广州510990

出　　处：《中南药学》2024年第10期2725-2728,共4页Central South Pharmacy

基　　金：广东省重大人才工程项目(No.210183503006);广东省实验室建设项目(No.2023B1212070029);广东省省级促进经济高质量发展专项(No.粤自然资合[2023]37)。

摘　　要：斑马鱼作为一种新型的实验动物模型,具有生命周期短、繁殖率高、胚胎发育迅速且透明、与人类疾病的基因和机制有着高度保守性等优点。这些特定的生理学优势使得斑马鱼被广泛应用于疾病研究和药物研发等领域,也被许多医药研发机构用来评价药物的疗效与安全性。斑马鱼可用于药物筛选、药效学评价、药代动力学研究及安全性评价等方面。然而斑马鱼模型也存在一些局限性,如缺乏实验技术方法的规范性和实验用动物的标准化。本文综述斑马鱼在药理毒理研究中的应用进展,以期为斑马鱼在临床前新药研发的应用中提供参考和帮助。As a novel laboratory animal model,zebrafish has short lifecycle,high reproduction rate,rapid embryonic development,and high similarity with genes and mechanism human diseases.These specific physiological advantages enable zebrafish to be widely used in disease research and drug development,as well as drug efficacy and safety evaluation in many pharmaceutical institutions.Zebrafish can be used in drug screening,pharmacokinetics,and safety evaluation.However,there are some limitations in the zebrafish model,such as lack of standardization of experimental techniques and animal standards.This papre reviewed the progress in the application of zebrafish in pharmacological and toxicological research,to provide references for further application of zebrafish in preclinical drug development.

关 键 词：斑马鱼 药理毒理 应用 

分 类 号：R-332[医药卫生]