免疫指标及Ranson评分与高脂血症性急性胰腺炎患者病情严重程度及预后的相关性分析  

Correlation analysis of immune indexes and Ranson scores with the condition and prognosis of hyperlipidemic acute pancreatitis

作　　者：孙姚 刘志军 刘微 SUN Yao;LIU Zhijun;LIU Wei(Xinyu People’s Hospital,Xinyu,Jiangxi,338025,China)

机构地区：[1]新余市人民医院,江西新余338025

出　　处：《当代医学》2024年第15期63-66,共4页Contemporary Medicine

摘　　要：目的分析免疫指标及Ranson评分与高脂血症性急性胰腺炎(HLAP)患者病情及预后的相关性。方法回顾性分析2019年1月至2022年10月新余市人民医院收治的68例HLAP患者的临床资料,按病情严重程度分为轻度组(n=35)、中度组(n=19)、重度组(n=14),并按入院28 d预后情况分为预后良好组(n=48)与预后不良组(n=20)。所有患者均行Ranson评分评估疾病严重程度,并检测血清免疫指标[白细胞介素-6(IL-6)、C反应蛋白(CRP)、降钙素原(PCT)]。比较各组Ranson评分及IL-6、CRP、PCT水平,分析Ranson评分及免疫指标与患者病情严重程度、预后的相关性。结果随着病情加重,HLAP患者Ranson评分及血清IL-6、CRP、PCT水平均明显升高,差异有统计学意义(P<0.05);轻度组Ranson评分及血清IL-6、CRP、PCT水平均低于中度组及重度组,且中度组低于重度组,差异有统计学意义(P<0.05)。预后良好组Ranson评分及血清IL-6、CRP、PCT水平均低于预后不良组,差异有统计学意义(P<0.05)。经Spearman相关性分析结果显示,Ranson评分及血清IL-6、CRP、PCT均与HLAP患者病情严重程度及预后呈正相关(r>0,P<0.05)。结论血清IL-6、CRP、PCT水平及Ranson评分均与HLAP患者病情严重程度及预后密切相关,可作为临床评估疗效及指导临床治疗的指标。Objective To analyze the correlation of immune indexes and Ranson score with the condition and prognosis of hyperlipidemic acute pancreatitis(HLAP).Methods The clinical data of 68 patients with HLAP admitted toXinyu People’s Hospitall from January 2019 to October 2022 were analyzed retrospectively,and they were divided into the mild group(n=35),the moderate group(n=19),and the severe group(n=14)according to the severity of the disease,and they were divided into the good prognosis group(n=48)and the bad prognosis group(n=20)according to the prognosis at 28 days after admission.Ranson scores were performed in all patients to assess disease severity,and serum immune indicators(interleukin-6[IL-6],C-reactive protein[CRP]and procalcitonin[PCT]were detected in all patients.Randon scores and the levels of IL-6,CRP and PCT were compared among each group,and the correlation between Ranson score and immune indexes and the severity of disease and prognosis of patients was analyzed.Results With the aggravation of the disease,the Ranson score and the levels of serum IL-6,CRP,PCT in HLAP patients were significantly increased,the differences were statistically significant(P<0.05);Ranson score and serum IL-6,CRP,PCT levels in the mild group were lower than those in the moderate group and the severe group,and the moderate group were lower than the severe group,the differences were statistically significant(P<0.05).Ranson score and serum IL-6,CRP,PCT levels in the good prognosis group were lower than those in the poor prognosis group,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that Ranson score,serum IL-6,CRP and PCT were positively correlated with the severity and prognosis of HLAP patients(r>0,P<0.05).Conclusion Ranson score and serum IL-6,CRP,PCT are closely related to the severity and prognosis of HLAP patients,and can be used as indicators for clinical evaluation of therapeutic effect and guidance of clinical treatment.

关 键 词：高脂血症性急性胰腺炎 RANSON评分 病情严重程度 预后 

分 类 号：R576[医药卫生—消化系统]