艾司西酞普兰与舍曲林对抑郁症伴焦虑症状患者的治疗效果分析  

Efficacy of Escitalopram and Sertraline in Patients with Depression and Anxiety Symptoms

作　　者：付裕 陈坤玲 李幸 Fu Yu;Chen Kunling;Li Xing(Department of Pharmacy,Zhumadian Second People’s Hospital,Zhumadian,Henan,463000,China)

机构地区：[1]驻马店市第二人民医院药学部,河南驻马店463000

出　　处：《黑龙江医学》2024年第20期2492-2494,共3页Heilongjiang Medical Journal

摘　　要：目的:探讨艾司西酞普兰与舍曲林对抑郁症伴焦虑症状患者的治疗效果。方法:选择2021年10月—2023年2月驻马店市第二人民医院收治的160例抑郁症伴焦虑症状患者,按照不同治疗方法分为对照组与观察组,对照组(80例)给予舍曲林治疗,观察组(80例)给予艾司西酞普兰治疗,对比两组患者临床疗效、抑郁程度、焦虑症状程度、不良反应发生情况。结果:治疗12周后,观察组总有效率(88.75%)较对照组(77.50%)高,差异无统计学意义(χ^(2)=2.488,P>0.05)。治疗前,两组患者汉密尔顿抑郁量表(HAMD)评分比较,差异无统计学意义(t=0.572,P>0.05);观察组治疗4周、8周后HAMD评分低于对照组,差异均有统计学意义(t=10.934、15.746,P<0.05),但治疗12周后两组间HAMD评分比较,差异无统计学意义(t=1.789,P>0.05)。治疗前,两组患者汉密尔顿抑郁量表(HAMA)评分比较,差异无统计学意义(t=0.377,P>0.05);观察组治疗4周、8周后HAMA评分低于对照组,差异均有统计学意义(t=13.694、22.196,P<0.05),但治疗12周后两组间HAMA评分比较,差异无统计学意义(t=1.899,P>0.05)。治疗12周后,观察组不良反应发生率为17.50%,低于对照组的38.75%,差异有统计学差异(χ^(2)=8.935,P<0.05)。结论:艾司西酞普兰与舍曲林均能有效治疗抑郁症伴焦虑症状患者,且艾司西酞普兰见效快、不良反应少、用药安全性较高,具有一定的临床应用价值。Objective:To investigate the effects of Escitalopram and sertraline on patients with depression and anxiety symptoms.Methods:Patients with depression and anxiety symptoms admitted to the hospital from October 2021 to February 2023 were divided into control group and observation group according to different treatment methods.80 cases in the control group were treated with sertraline,and 80 cases in the observation group were treated with escitalopram.The clinical efficacy,degree of depression,degree of anxiety symptoms and occurrence of adverse reactions were compared between the two groups.Results:After 12 weeks of treatment,the total effective rate of observation group(88.75%)was higher than that of control group(77.50%),and there was no statistical difference between the two groups(χ^(2)=2.488,P>0.05).Before treatment,there was no significant difference in HAMD scores between the two groups(χ^(2)=0.572,P>0.05).HAMD scores in the observation group were lower than those in the control group after 4 and 8 weeks of treatment(t=10.934,15.746;P<0.05),but there was no significant difference in HAMD scores between the two groups after 12 weeks of treatment(t=1.789,P>0.05).Before treatment,there was no significant difference in HAMA scores between the two groups(t=0.377,P>0.05).The HAMA scores of the observation group were lower than those of the control group after 4 and 8 weeks of treatment(t=13.694,22.196;P<0.05),but there was no significant difference in HAMA scores between the two groups after 12 weeks of treatment(t=1.899,P>0.05).After 12 weeks of treatment,the incidence of adverse reactions was 17.50%in the observation group and 38.75%in the control group(χ^(2)=8.935,P<0.05).Conclusion:Both Escitalopram and sertraline can effectively treat patients with depression and anxiety symptoms,and Escitalopram has fast effect,with few adverse reactions and high drug safety.It has certain clinical application value.

关 键 词：艾司西酞普兰 舍曲林 抑郁症 焦虑症状 临床疗效 

分 类 号：R749.72[医药卫生—神经病学与精神病学]