化学试剂诱导炎性结直肠癌动物模型的研究进展  

Research progress in animal models of inflammatory colorectal cancer induced by chemical agents

作　　者：曾沙 王隽 李萍[1] 高景莘[1] 徐海波[2] ZANG Sha;WANG Juan;LI Ping;GAO Jing-xing;XU Hai-bo(Department of Traditional Chinese Medicine Pharmacy,Chengdu Integrated Traditional Chinese and Western Medicine Hospital,Chengdu 610095,China;Department of Pharmacology,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都市中西医结合医院中药剂科,四川成都610095 [2]成都中医药大学,四川成都610075

出　　处：《西南民族大学学报（自然科学版）》2024年第5期534-543,共10页Journal of Southwest Minzu University(Natural Science Edition)

基　　金：国家自然科学基金项目(81573813,81173598);四川省教育厅省属高校科研创新团队建设计划项目(18TD0017)。

摘　　要：炎症性肠病是导致结直肠癌发生的直接因素.结合炎症相关结直肠癌的发病分子机制,对现有化学试剂诱导的结肠癌动物模型进行系统的整理和比较.发现AOM/DSS诱导的结直肠癌是目前应用最广泛,操作较简单,成模率较高,病理表现、机制与临床CRC特征更为相似的良好模型之一.Inflammatory bowel disease is a direct factor leading to the development of colorectal cancer(CRC).The existing animal models of colorectal cancer induced by chemical agents were systematically reviewed and compared.It was found that colorectal cancer induced by AOM/DSS was one of the most widely used models with simple operation,high modeling rate,and more similar pathological features and mechanisms to clinical CRC.

关 键 词：结直肠癌 炎症性肠病 氧化偶氮甲烷 葡聚糖硫酸钠 1 2-二甲肼 2 4 6-三硝基苯磺酸 动物模型 

分 类 号：R735.3[医药卫生—肿瘤] R965.1[医药卫生—临床医学]