真实世界环境下外周血炎性指标对创伤性颅脑损伤后抑郁障碍的预测价值  

The predictive value of peripheral blood inflammatory indicators for depressive disorder following traumatic brain injury in real-world setting

作　　者：程远驰 韩闯闯 徐立 杨珍 徐峰[3] CHENG Yuanchi;HAN Chuangchuang;XU Li;YANG Zhen;XU Feng(Department of Neurosurgery,the South Branch of the Sixth People’s Hospital affiliated to Shanghai University of Medicine&Health Science,Shanghai 201499,China;Department of Pharmacy,the 906th Hospital of the Chinese People’s Liberation Army Joint Logistic Support Force,Ningbo 315040,China;Department of Pharmacy,the South Branch of the Sixth People’s Hospital affiliated to Shanghai Jiao Tong University,Shanghai 201499,China)

机构地区：[1]上海健康医学院附属第六人民医院南院神经外科,上海201499 [2]中国人民解放军联勤保障部队第906医院药剂科,宁波315040 [3]上海交通大学附属第六人民医院南院药剂科,上海201499

出　　处：《上海医药》2024年第17期53-57,共5页Shanghai Medical & Pharmaceutical Journal

基　　金：国家自然科学基金面上项目(82272255);上海健康医学院科研基金资助项目(SFP-22-22-15-001)。

摘　　要：目的:探讨真实世界环境下外周血炎性指标预测创伤性颅脑损伤(traumatic brain injury,TBI)后抑郁障碍的临床价值。方法:招募TBI患者67例,随访3个月后根据是否有抑郁障碍将患者分为对照组和抑郁组,筛选TBI后抑郁障碍发生的影响因素。结果:颅内感染是影响TBI后抑郁障碍发生的独立影响因素。外周血白细胞计数、中性粒细胞百分比、CRP水平与TBI患者抑郁程度呈正相关。结论:TBI后抑郁障碍发生率较高,外周血白细胞计数、中性粒细胞百分比、CRP水平有望作为早期诊断TBI后抑郁障碍的标志物。Objective:To investigate the clinical value of peripheral blood inflammatory indicators for depressive disorder following traumatic brain injury(TBI)in real-world setting.Methods:Sixty-seven TBI patients were recruited and divided into a control group and a depression group after three months of follow-up.The influencing factors for the occurrence of depressive disorder after TBI were screened.Results:Intracranial infection was an independent factor affecting the occurrence of depressive disorder.White cell count,neutrophil percentage and CRP level in peripheral blood were all positively correlated with the depression in TBI patients.Conclusion:The incidence of depressive disorder after TBI is high,and the white cell count,neutrophil percentage and CRP level in peripheral blood are expected to be used as markers for early diagnosis of depressive disorder after TBI.

关 键 词：创伤性颅脑损伤 抑郁障碍 颅内感染 炎性指标 早期诊断 

分 类 号：R749.12[医药卫生—神经病学与精神病学]