保留胃窦的调节型双通道消化道重建术对进展期胃癌患者肿瘤标志物水平及营养状态的影响  

Effects of regulated dual channel digestive tract reconstruction surgery with gastric antrum preservation on tumor marker level and nutritional status in patients with advanced gastric cancer

作　　者：韩朝 焦瑞 王增库 梁刚 郭栋 HAN Zhao;JIAO Rui;WANG Zengku;LIANG Gang;GUO Dong(No.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000;Shenmu Hospital Affiliated to Northwest University/Shenmu Hospital,Yulin 719300,China)

机构地区：[1]陕西省核工业二一五医院,陕西咸阳712000 [2]西北大学附属神木医院/神木市医院,陕西榆林719300

出　　处：《临床医学研究与实践》2024年第28期23-26,共4页Clinical Research and Practice

基　　金：2020年榆林市科协青年人才托举计划项目(No.20200232)。

摘　　要：目的 探讨保留胃窦的调节型双通道消化道重建术对进展期胃癌患者肿瘤标志物水平及营养状态的影响。方法 选取2020年1月至2023年1月收治的100例进展期胃癌患者,将其随机分为对照组和观察组,各50例。对照组采用全胃切除Roux-en-Y吻合术,观察组采用保留胃窦的调节型双通道消化道重建术。比较两组的治疗效果。结果 术后2周,观察组的癌胚抗原(CEA)、糖类抗原19-9(CA19-9)、糖类抗原72-4(CA72-4)水平低于对照组(P<0.05)。术后2周,观察组的前白蛋白(PA)、白蛋白(ALB)、铁蛋白(SF)水平高于对照组(P<0.05)。术后2周,两组的胃泌素(GAS)、胆囊收缩素(CCK)水平均降低,但观察组高于对照组(P<0.05)。观察组的并发症总发生率低于对照组(P<0.05)。结论 保留胃窦的调节型双通道消化道重建术用于进展期胃癌患者的效果较好,可下调肿瘤标志物水平,改善营养状态。Objective To investigate the effects of regulated dual channel digestive tract reconstruction surgery with gastric antrum preservation on tumor marker levels and nutritional status in patients with advanced gastric cancer.Methods A total of 100 patients with advanced gastric cancer admitted from January 2020 to January 2023 were selected and randomly divided into control group and observation group,with 50 cases in each group.The control group was treated with total gastrectomy Roux-en-Y anastomosis,and the observation group was treated with regulated dual channel digestive tract reconstruction surgery with gastric antrum preservation.The therapeutic effects of the two groups were compared.Results At 2 weeks after operation,the levels of carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9)and carbohydrate antigen 72-4(CA72-4)in the observation group were lower than those in the control group(P<0.05).At 2 weeks after operation,the levels of prealbumin(PA),albumin(ALB)and serum ferritin(SF)in the observation group were higher than those in the control group(P<0.05).At 2 weeks after operation,the levels of gastrin(GAS)and cholecystokinin(CCK)in the two groups decreased,but those in the observation group were higher than the control group(P<0.05).The total incidence of complications in the observation group was lower than that in the control group(P<0.05).Conclusion Regulated dual channel digestive tract reconstruction surgery with gastric antrum preservation is effective in patients with advanced gastric cancer,which can reduce the tumor markers levels and improve nutritional status.

关 键 词：保留胃窦 调节型双通道消化道重建术 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]