大剂量维生素C联合乌司他丁、生长抑素治疗急性胰腺炎的效果及对肝肾功能的影响  

Effect of high-dose vitamin C combined with ulinastatin and somatostatin in the treatment of acute pancreatitis and its influence on liver and kidney function

作　　者：宋小利[1] 陈璐 SONG Xiaoli;CHEN Lu(Traditional Chinese Medicine Hospital of Baoji,Baoji 721000,China)

机构地区：[1]宝鸡市中医医院,陕西宝鸡721000

出　　处：《临床医学研究与实践》2024年第28期39-42,共4页Clinical Research and Practice

摘　　要：目的 探讨大剂量维生素C联合乌司他丁、生长抑素治疗急性胰腺炎的效果及对肝肾功能的影响。方法择取2020年2月至2022年3月收治的100例急性胰腺炎患者作为研究对象,按照随机数字表法将其分为对照组和观察组,各50例。对照组采用乌司他丁、生长抑素治疗,观察组在对照组基础上加用大剂量维生素C治疗。比较两组的临床疗效、肝肾功能指标、脂肪酸结合蛋白4(FABP4)、miR-369-5p表达。结果 观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的淀粉酶(AMY)、谷氨酸氨基转移酶(ALT)、血尿素氮(BUN)、血肌酐(Scr)水平比较,差异无统计学意义(P>0.05);治疗后,观察组的AMY、ALT、BUN、Scr水平低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的FABP4、miR-369-5p表达水平比较,差异无统计学意义(P>0.05);治疗后,观察组的FABP4水平低于对照组,miR-369-5p表达水平高于对照组,差异具有统计学意义(P<0.05)。结论 大剂量维生素C联合乌司他丁、生长抑素治疗急性胰腺炎患者不仅能够提升整体疗效,还能促进肝肾功能恢复,并调节FABP4、miR-369-5p水平,值得推广。Objective To investigate the effect of high-dose vitamin C combined with ulinastatin and somatostatin in the treatment of acute pancreatitis and its influence on liver and kidney function.Methods A total of 100 patients with acute pancreatitis admitted from February 2020 to March 2022 were selected as the research objects and divided into control group and observation group by random number table method,with 50 cases in each group.The control group was treated with ulinastatin and somatostatin,and the observation group was treated with high-dose vitamin C on the basis of the control group.The clinical efficacy,liver and kidney function indexes,fatty acid binding protein 4(FABP4)and miR-369-5p expression were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant difference in the levels of amylase(AMY),alanine aminotransferase(ALT),blood urea nitrogen(BUN)and serum creatinine(Scr)between the two groups(P>0.05);after treatment,the levels of AMY,ALT,BUN and Scr in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the expression levels of FABP4 and miR-369-5p between the two groups(P>0.05);after treatment,the level of FABP4 in the observation group was lower than that in the control group,the expression level of miR-369-5p was higher than that in the control group,and the differences were statistically significant(P<0.05).Conclusion High-dose vitamin C combined with ulinastatin and somatostatin in the treatment of patients with acute pancreatitis can not only improve the overall efficacy,but also promote the recovery of liver and kidney function,and regulate the levels of FABP4 and miR-369-5p,which is worth promoting.

关 键 词：大剂量维生素C 乌司他丁 生长抑素 急性胰腺炎 肝肾功能 

分 类 号：R576[医药卫生—消化系统]