血塞通联合倍他司汀对后循环缺血性眩晕患者椎-基底动脉血流动力学的影响  

Effect of Xuesaitong combined with betahistine on hemodynamics of vertebrobasilar artery in patients with posterior circulation ischemic vertigo

作　　者：江雪娇 秦西婷 JIANG Xuejiao;QIN Xiting(Neurology Department,Xi'an Tangcheng Hospital,Xi'an 710016,China)

机构地区：[1]西安唐城医院神经内科,陕西西安710016

出　　处：《临床医学研究与实践》2024年第28期51-54,共4页Clinical Research and Practice

摘　　要：目的 探讨血塞通联合倍他司汀对后循环缺血性眩晕患者椎-基底动脉血流动力学的影响。方法 选取2021年1月至2022年12月西安唐城医院神经内科收治的80例后循环缺血性眩晕患者作为研究对象,根据用药方案不同将其分为常规组(40例,倍他司汀)和观察组(40例,血塞通联合倍他司汀)。比较两组的治疗效果。结果 观察组的治疗总有效率高于常规组,差异具有统计学意义(P<0.05)。治疗后,观察组的血浆黏度(PV)、全血黏度(WBV)、血小板聚集率(PAR)、红细胞比容(HCT)低于常规组(P<0.05)。治疗后,观察组椎-基底动脉最大血流速度(Vmax)、最小血流速度(Vmin)、平均血流量(Qmean)及降钙素基因相关肽(CGRP)水平高于常规组,外周阻力(RV)及内皮素-1(ET-1)水平低于常规组(P<0.05)。两组的不良反应总发生率无明显差异(P>0.05);随访1年,观察组的复发率显著低于常规组(P<0.05)。结论 血塞通联合倍他司汀可有效调节后循环缺血性眩晕患者血液流变学指标及椎-基底动脉的血流动力学指标,改善机体血液循环,取得安全、高效的理想效果。Objective To investigate the effect of Xuesaitong combined with betahistine on hemodynamics of vertebrobasilar artery in patients with posterior circulation ischemic vertigo.Methods A total of 80 patients with posterior circulation ischemic vertigo admitted in the neurology department of Xi'an Tangcheng Hospital from January 2021 to December 2022 were selected as the research objects,and the patients were divided into conventional group(40 cases,betahistine)and observation group(40 cases,Xuesaitong combined with betahistine)according to different medication regimens.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the conventional group,and the difference was statistically significant(P<0.05).After treatment,the plasma viscosity(PV),whole blood viscosity(WBV),platelet aggregation rate(PAR)and hematocrit(HCT)in the observation group were lower than those in the conventional group(P<0.05).After treatment,the maximum blood flow velocity(Vmax),minimum blood flow velocity(Vmin),mean blood flow(Qmean)of vertebrobasilar artery and calcitonin generelated peptide(CGRP)level in the observation group were higher than those in the conventional group,and the peripheral resistance(RV)and endothelin-1(ET-1)level were lower than those in the conventional group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05);after 1 year of follow-up,the recurrence rate of the observation group was significantly lower than that of the conventional group(P<0.05).Conclusion Xuesaitong combined with betahistine can effectively regulate the hemorheological indexes and the hemodynamic indexes of vertebrobasilar artery of patients with posterior circulation ischemic vertigo,improve the blood circulation of the body,and achieve safe and efficient ideal results.

关 键 词：血塞通 倍他司汀 后循环缺血性眩晕 椎-基底动脉 血流动力学 

分 类 号：R743.3[医药卫生—神经病学与精神病学]