荜铃胃痛颗粒联合质子泵抑制剂治疗老年性胃食管反流病临床研究  

Clinical study of Beling Weitong granule combined with proton pump inhibitors in senile gastroesophageal reflux disease

作　　者：叶明坤 陈勇 周成鹏 邓春洪 吕一品 Ye Mingkun;Chen Yong;Zhou Chengpeng;Deng Chunhong;Lyu Yipin(Department of Gastroenterology,the Second People′s Hospital of Dujiangyan,Dujiangyan 611830,China;Department of Gastroenterology,General Hospital of Eastern Theater Command,Chengdu 610083,China)

机构地区：[1]都江堰市第二人民医院消化内科,都江堰611830 [2]中国人民解放军西部战区总医院消化内科,成都610083

出　　处：《中国医师进修杂志》2024年第10期908-912,共5页Chinese Journal of Postgraduates of Medicine

基　　金：四川省中央引导地方科技发展专项项目(2022ZYD0071)。

摘　　要：目的探讨荜铃胃痛颗粒联合质子泵抑制剂治疗老年性胃食管反流病的临床疗效。方法回顾性选择都江堰市第二人民医院2020年1月至2021年12月收治的186例老年性胃食管反流病患者为研究对象,其中93例采用质子泵抑制剂(奥美拉唑)口服(对照组),93例采用荜铃胃痛颗粒联合奥美拉唑口服(联合组),两组均治疗8周。比较两组治疗前后症候评分、以反流症状为主的问卷调查(GERDQ)评分、临床疗效和治疗前后血清胃泌素-17(G-17)、胃动素(MTL)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平及安全性。结果联合组治疗后症候评分、GERDQ评分低于对照组[(8.28±2.57)分比(15.68±3.69)分、(8.15±2.23)分比(10.50±2.45)分],差异有统计学意义(P<0.05)。联合组治疗后总有效率高于对照组[96.77%(90/93)比87.10%(81/93)],差异有统计学意义(χ^(2)=5.87,P<0.05)。联合组治疗后血清G-17、MTL水平高于对照组[(7.48±0.96)pmol/L比(6.55±0.83)pmol/L、(206.96±37.83)pg/L比(184.75±35.69)pg/L],IL-6、TNF-α水平低于对照组[(9.38±1.92)ng/L比(14.13±2.04)ng/L、(9.41±1.85)ng/L比(12.01±2.11)ng/L],差异均有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论荜铃胃痛颗粒联合质子泵抑制剂治疗老年性胃食管反流病效果较好,并且安全。Objective To explore the clinical effect of Beling Weitong granule combined with proton pump inhibitors in senile gastroesophageal reflux disease(GERD).Methods A total of 186 patients with GERD treated in the Second People′s Hospital of Dujiangyan from January 2020 to December 2021 were retrospectively selected as the study subjects,of which 93 patients received proton pump inhibitor(prilosec)orally(control group)and 93 patients received Beling Weitong granule combined with prilosec orally(combination group).Both groups were treated for 8 weeks.Symptom score,reflux symptom-based questionnaire(GERDQ)score,clinical efficacy,serum levels of gastrin-17(G-17),motilin(MTL),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)before and after treatment and safety were compared between the two groups.Results After treatment,the symptom score and GERDQ score in the combination group were lower than those in the control group:(8.28±2.57)scores vs.(15.68±3.69)scores,(8.15±2.23)scores vs.(10.50±2.45)scores,there were statistical differences(P<0.05).The total effective rate in the combination group was higher than that in the control group:96.77%(90/93)vs.87.10%(81/93),there was statistical difference(χ^(2)=5.87,P<0.05).After treatment,the levels of serum G-17 and MTL in the combination group were higher than those in the control group,the levels of IL-6 and TNF-αwere lower than those in the control group:(7.48±0.96)pmol/L vs.(6.55±0.83)pmol/L,(206.96±37.83)pg/L vs.(184.75±35.69)pg/L,(9.38±1.92)ng/L vs.(14.13±2.04)ng/L,(9.41±1.85)ng/L vs.(12.01±2.11)ng/L,there were statistical differences(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Beling Weitong granule combined with proton pump inhibitor in the treatment of senile gastroesophageal reflux disease is effective,and it is safe.

关 键 词：胃食管反流 质子泵抑制剂 老年人 荜铃胃痛颗粒 

分 类 号：R571[医药卫生—消化系统]