抗Hu抗体对胃肠动力障碍性疾病神经系统损伤机制的研究进展  

Progress in Pathogenesis of Nervous System Injury in Gastrointestinal Motility Disorders Caused by Anti⁃Hu Antibody

作　　者：付铭玉 方秀才[1] FU Mingyu;FANG Xiucai(Department of Gastroenterology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100730)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院消化内科,100730

出　　处：《胃肠病学》2024年第2期104-108,共5页Chinese Journal of Gastroenterology

基　　金：国家重点研发计划课题(2022YFC2504004)。

摘　　要：越来越多的研究提示靶向神经元抗体特别是抗Hu抗体可对中枢神经系统和(或)肠神经系统造成不同程度的损伤,影响相关疾病的发生、发展和预后,因此明确这类抗体对神经系统损伤的机制及其与疾病的相关性对个体化诊断和治疗具有重要指导意义。本文就抗Hu抗体与副肿瘤性胃肠动力障碍性疾病、慢性假性肠梗阻、肠易激综合征等疾病的相关性及其对神经元的损伤机制作一综述。More and more studies suggest that targeting neuronal antibodies,particularly antiHu antibody,can cause various degrees of damage to central nervous system and/or enteric nervous system and affect the occurrence,progression,and prognosis of related diseases.Therefore,elucidating the mechanisms of antiHu antibodyinduced nervous system injury and its relevance to diseases is of significant importance for individualized diagnosis and treatment.This article reviewed the associations between antiHu antibody and paraneoplastic gastrointestinal dysmotility,chronic intestinal pseudoobstruction,and irritable bowel syndrome,as well as the mechanisms of neuronal damage caused by antiHu antibody.

关 键 词：抗Hu抗体 神经系统损伤 胃肠动力障碍 副肿瘤综合征 神经系统 肠假性梗阻 肠易激综合征 

分 类 号：R57[医药卫生—消化系统]