乳糜泻与微量元素相关性研究进展  

Progress of Research on Correlation Between Celiac Disease and Trace Elements

作　　者：凯丽比努尔·努尔麦麦提 李婷[2,3] 高峰 Kailibinuer·NUERMAIMAITI;LI Ting;GAO Feng(Graduate School of Xinjiang Medical University,Urumqi,830054;Department of Gastroenterology,the People′s Hospital of Xinjiang Uygur Autonomous Region,Urumqi;Xinjiang Clinical Medical Research Center for Digestive Diseases,Urumqi)

机构地区：[1]新疆医科大学研究生学院,830054 [2]新疆维吾尔自治区人民医院消化科 [3]新疆消化系统疾病临床医学研究中心

出　　处：《胃肠病学》2024年第2期114-118,共5页Chinese Journal of Gastroenterology

基　　金：国家自然科学基金(82260116)。

摘　　要：乳糜泻是一种由遗传易感个体摄入麸质引起的自身免疫病,主要累及小肠,引起小肠绒毛萎缩。许多乳糜泻患者因肠道炎症出现各种营养素吸收障碍,导致体内营养失衡,包括各种微量元素失衡。虽然微量元素在人体中含量很少,但因其特殊生理功能,对人体健康具有重要作用。部分乳糜泻相关并发症与不同微量元素失衡有关。此外,研究发现多种微量元素在乳糜泻发生、发展中发挥作用。本文就乳糜泻患者中一些重要微量元素水平,以及近年各种微量元素在乳糜泻发病机制、病情评估和治疗中作用的研究进展作一综述。Celiac disease,an autoimmune disease caused by the intake of gluten in genetically susceptible individuals,mainly affects the small intestine,causing villous atrophy of the small intestine.Many celiac disease patients suffer from various nutrient absorption disorders due to intestinal inflammation,leading to nutritional imbalance,including the imbalance of various trace elements.Although the amount of trace elements in human body is very low,all kinds of trace elements are closely related to human health because of their special physiological functions.Some of the complications of celiac disease are thought to be correlated with various trace element imbalances.In addition,many studies have found that various trace elements play roles in the occurrence and development of celiac disease.This article reviewed the levels of some important trace elements in patients with celiac disease,and the progress of research on the roles of various trace elements in the pathogenesis,disease assessment and treatment of celiac disease in recent years.

关 键 词：乳糜泻 微量元素 铁 锌 硒 铜 膳食 无麸质 

分 类 号：R574[医药卫生—消化系统]