基于病毒载体的神经病理性疼痛靶向基因治疗  

Targeted gene therapy for neuropathic pain based on viral vectors

作　　者：张魏怡 栾永[1] 宋辛叶 ZHANG Wei-yi;LUAN Yong;SONG Xin-ye(Department of Anesthesiology,First Affiliated Hospital of Dalian Medical University,Dalian 116014,China)

机构地区：[1]大连医科大学附属第一医院麻醉科,大连116014

出　　处：《中国疼痛医学杂志》2024年第10期764-768,共5页Chinese Journal of Pain Medicine

基　　金：国家自然科学基金(31971243)。

摘　　要：神经病理性疼痛(neuropathic pain,NP)是由躯体感觉系统的损害或疾病导致的疼痛,严重影响病人的生理和心理健康。但目前的治疗效果往往并不理想。基因治疗是一种新兴的治疗策略,在诸多研究中已经证实病毒载体介导的基因治疗能够缓解NP。因此,本文根据NP的病理生理机制作为理论依据,讨论了基于病毒载体缓解NP的基因治疗,并对不同靶点的基因治疗进行归纳。对未来NP的研究方向提供了有益的参考和治疗思路。Neuropathic pain(NP)is defined as pain resulting from lesions or diseases of the somatosensory system,significantly impacting patients'physiological and psychological well-being.However,current treatment effect is often not ideal.As an emerging treatment strategy,gene therapy has been showed in various studies to alleviate NP via virus vector-mediated approaches.Therefore,based on the pathological and physiological mechanisms of NP,this article focuses on discussing gene therapy based on viral vectors to alleviate NP and summarizes gene therapy targeting different targets.This provides useful references and treatment insights for future research directions in the field of NP.

关 键 词：神经病理性疼痛 病毒载体 基因治疗 

分 类 号：R741[医药卫生—神经病学与精神病学] R450[医药卫生—临床医学]