The causal role of immune cells in susceptibility and severity of COVID-19:A bidirectional Mendelian randomization study  

作　　者：Weifeng Shang Hang Qian Sheng Zhang Xiaojun Pan Sisi Huang Zhenliang Wen Jiao Liu Dechang Chen 

机构地区：[1]Department of Critical Care Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China

出　　处：《Journal of Intensive Medicine》2024年第4期537-538,共2页重症医学（英文）

基　　金：supported by the National Natural Science Foundation of China(grant numbers:82241044 and 82172152);the Science and Technology Commission of Shanghai(grant numbers:22692192200).

摘　　要：To the Editor,Previous studies have demonstrated close associations of specific immune cell profiles in the occurrence and development of COVID-19.[1,2]However,due to confounding factors and reverse causality in traditional observational studies,it remains unclear whether these associations reflect a causal link.Mendelian randomization(MR)is a reliable method of causal inferences that uses genetic variants(usually single-nucleotide polymorphisms[SNPs])as instrumental variables(IVs)to estimate the causal effect of exposure on outcome.

关 键 词：SEVERITY IMMUNE RANDOM 

分 类 号：R563.1[医药卫生—呼吸系统] R392[医药卫生—内科学]