Protein hydrogels for biomedical applications  

作　　者：Xinyi Wang Yue Hou Xiong Lu Chaoming Xie Yanan Jiang 

机构地区：[1]Institute of Biomedical Engineering,College of Medicine,Southwest Jiaotong University,Chengdu,Sichuan,China [2]Key Lab of Advanced Technologies of Materials,Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu,Sichuan,China [3]Obesity and Metabolism Medicine-Engineering Integration Laboratory,Department of General Surgery,The Third People's Hospital of Chengdu,The Affiliated Hospital of Southwest Jiaotong University,Chengdu,Sichuan,China

出　　处：《Biosurface and Biotribology》2024年第3期106-131,共26页生物表面与生物摩擦学（英文）

基　　金：China Postdoctoral Science Foundation,Grant/Award Number:2023M742897;Guangdong Basic and Applied Basic Research Foundation,Grant/Award Number:2021B1515120019;Postdoctoral Fellowship Program of CPSF,Grant/Award Number:GZC20232192;Fundamental Research Funds for the Central Universities of Beijing University of Chemical Technology,Grant/Award Number:2682023ZTPY056;Sichuan Science and Technology Program,Grant/Award Number:2023ZYD0114;National Key Research and Development Program of China Stem Cell and Translational Research,Grant/Award Number:2023YFC2411300;National Natural Science Foundation of China,Grant/Award Numbers:82072071,82072073;New Interdisciplinary Cultivation Fund of SWJTU,Grant/Award Numbers:2682023JX005,2682022KJ041。

摘　　要：Hydrogels,characterised as highly hydrophilic three-dimensional polymer networks,have gained increasing attention due to their unique physicochemical properties,finding applications in various fields.Natural polymer hydrogels exhibit higher biocompatibility and biodegradability compared to traditional synthetic polymer hydrogels.Proteins,being the principal materials of natural polymer hydrogels,bear numerous modifiable functional groups.The resultant hydrogel possesses responsiveness,adjustable degradability,and underway as an excellent biomaterial.Seven common raw materials used to construct protein hydrogels are introduced.In terms of comparing natural polymer hydrogels with traditional synthetic polymer hydrogels,the authors conduct a detailed analysis and comparison,highlighting the advantages of natural polymer hydrogels in terms of biocompatibility and biodegradability,and summarising their characteristics.The authors also address the limitations of various protein hydrogels and list existing strengthening cross-linking strategies,proposing new insights to overcome the application limits of protein hydrogels.Additionally,the applications of protein hydrogels in drug delivery,biosensing,bio-inks and tissue engineering are discussed.The authors conclude by summarising the current challenges faced by protein hydrogels and prospecting its future development.

关 键 词：BIOMATERIALS biomedical application 

分 类 号：TQ427.26[化学工程] R318[医药卫生—生物医学工程]