安宫牛黄丸辅助治疗急性高血压性出血性脑卒中临床研究  

Clinical Study on Adjuvant Treatment of Acute Hypertensive Intracerebral Hemor⁃rhage with Angong Niuhuang Pills

作　　者：施顺孝 盛文国 龙连圣 吴钟华 王伟 谢虎 方文杰 莫成平 王梦凡 SHI Shunxiao;SHENG Wenguo;LONG Liansheng;WU Zhonghua;WANG Wei;XIE Hu;FANG Wenjie;MO Chengping;WANG Mengfan(Department of Neurosurgery,South Taihu Hospital Affiliated to Huzhou College,Huzhou Zhejiang 313000,China)

机构地区：[1]湖州学院附属南太湖医院神经外科,浙江湖州313000

出　　处：《新中医》2024年第19期50-54,共5页New Chinese Medicine

基　　金：浙江省医学会临床科研基金项目(2021ZYC-A140)。

摘　　要：目的:观察安宫牛黄丸辅助治疗急性高血压性出血性脑卒中(HICH)的临床疗效。方法:选择50例HICH患者,采用随机数字表法分为观察组和对照组各25例。对照组给予常规基础治疗,观察组在对照组基础上联合安宫牛黄丸治疗。评价2组临床疗效,比较2组治疗前后中医证候积分、美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分、血清学指标。结果:观察组总有效率为96.00%,高于对照组72.00%(P<0.05)。治疗后,2组中医证候积分、NIHSS评分、mRS评分均低于治疗前(P<0.05),且观察组中医证候积分、NIHSS评分、mRS评分低于对照组(P<0.05)。治疗后,2组血清1-磷酸鞘氨醇(S1P)水平高于治疗前,脂多糖结合蛋白(LBP)、8-羟基脱氧鸟苷酸(8-OHdG)水平均低于治疗前(P<0.05),且观察组S1P水平高于对照组,LBP、8-OHdG水平低于对照组(P<0.05)。结论:安宫牛黄丸应用于HICH中临床疗效显著,可有效改善患者临床症状,提高神经功能,降低炎症反应。Objective:To observe the clinical effect of Angong Niuhuang Pills as an adjuvant therapy for acute hypertensive intracerebral hemorrhage(HICH).Methods:A total of 50 HICH patients were selected and randomly divided into the observation group and the control group,with 25 cases in each group,using a random number table method.The control group received routine basic treatment,and the observation group received combined treatment with Angong Niuhuang Pills on the basis of the control group.Evaluated the clinical effects of the two groups,and compared the traditional Chinese medicine(TCM)syndrome scores,National Institutes of Health Stroke Scale(NIHSS)scores,modified Rankin Scale(mRS)scores,and serological indicators before and after treatment.Results:The total effective rate was 96.00%in the observation group,which was higher than that of 72.00%in the control group(P<0.05).After treatment,the TCM syndrome scores,NIHSS scores,and mRS scores in both groups were lower than those before treatment(P<0.05),and the TCM syndrome score,NIHSS score,and mRS score in the observation group were lower than those in the control group(P<0.05).After treatment,the serum levels of sphingosine 1-phosphate(S1P)in both groups were higher than those before treatment,and the levels of lipopolysaccharide binding protein(LBP)and 8-hydroxydeoxyguanosine(8-OHdG)were lower than those before treatment(P<0.05);the S1P level in the observation group was higher than that in the control group,and the LBP and 8-OHdG levels were lower than those in the control group(P<0.05).Conclusion:The clinical efficacy of Angong Niuhuang Pills in HICH is significant,which can effectively improve the clinical symptoms of patients,enhance neurological function,and reduce inflammatory reactions.

关 键 词：高血压性出血性脑卒中 痰热内闭清窍证 安宫牛黄丸 神经功能 炎症因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]