饮食因素与子痫前期因果关系的孟德尔随机化分析  

Mendelian randomization analysis of causality between dietary factors and preeclampsia

作　　者：张展 李建锋 李燕玲[1] 王博雯[1] 昂文成林龙珠 王鑫[2] 张小明 谢萍[1] ZHANG Zhan;LI Jianfeng;LI Yanling;WANG Bowen;ANGWEN Chenglinlongzhu;WANG Xin;ZHANG Xiaoming;XIE Ping(Department of Cardiovascular Medicine,Gansu Provincial People's Hospital;The First Clinical College of Gansu University of Traditional Chinese Medicine;The First Clinical Medical College of Lanzhou University,lanzhou 730000,Gansu,China)

机构地区：[1]甘肃省人民医院心血管内科 [2]甘肃中医药大学第一临床医学院 [3]兰州大学第一临床医学院,甘肃兰州730000

出　　处：《山东大学学报（医学版）》2024年第8期59-66,共8页Journal of Shandong University:Health Sciences

基　　金：甘肃省国际科技合作项目(20YF3WA011);兰州市人才创新创业项目(2018-RC-72);甘肃省中医药科研项目(GZKZ-2021-7);甘肃省人民医院优秀博士生培育计划(22GSSYD-14)。

摘　　要：目的 探讨饮食因素与子痫前期的可能因果效应。方法 利用全基因组关联研究(genome-wide association studies, GWAS)数据,采用逆方差加权法(inverse-variance weighted, IVW)、加权中位数(weighted median, WM)、MR Egger回归(MR-Egger regression)进行孟德尔随机化(Mendelian randomization, MR)分析,评估饮食因素与子痫前期的因果关系。并且,进行异质性检验、敏感性分析、多效性分析。结果 奶酪摄入量(IVW:OR=0.504, 95%CI:0.314~0.808,P=0.004)、沙拉/生蔬菜摄入量(IVW:OR=0.195, 95%CI:0.041~0.923,P=0.039)与子痫前期存在负向因果关系。且所有结果均不存在多效性,留一法亦提示所得结果稳健。其他饮食因素未发现与子痫前期具有因果关系。结论 这项双样本MR分析发现奶酪摄入量、沙拉/生蔬菜摄入量与欧洲人群子痫前期风险降低有关,但仍需更大的GWAS数据进一步验证这种关系,同时研究其中潜在关联机制,以支持该结论。此外,其他饮食因素未发现与子痫前期具有因果关系。Objective To explore the potential causal link between dietary factors and preeclampsia.Methods By leveraging Genome-wide association studies(GWAS)data,Mendelian randomization(MR)analyses were employed utilizing Inverse-variance weighted(IVW),Weighted median(WM),and MR-Egger regression techniques to assess the causal association between dietary factors and preeclampsia.Furthermore,heterogeneity tests,sensitivity analyses,and pleiotropy assessments to were conducted ensure the robustness of the findings.Results The analysis revealed a negative causal relationship between preeclampsia and the consumption of cheese(IVW:OR=0.504,95%CI:0.314-0.808,P=0.004)as well as salads/raw vegetables(IVW:OR=0.195,95%CI:0.041-0.923,P=0.039).All results demonstrated an absence of pleiotropic effects,and the leave-one-out approach further validated the robustness of the findings.No causal associations were observed between preeclampsia and other dietary factors examined.Conclusion A reduced risk of preeclampsia associated with cheese intake and the consumption of salads/raw vegetables is identified in European populations.However,confirmation of these relationships and exploration of the underlying mechanisms require validation using larger GWAS datasets.Additionally,no causal links are established between preeclampsia and the remaining dietary factors investigated.

关 键 词：饮食 奶酪 蔬菜 子痫前期 孟德尔随机化 

分 类 号：R714.7[医药卫生—妇产科学] R459.3[医药卫生—临床医学]