抗菌光动力疗法治疗口源性口臭的系统评价  

Systematic evaluation of antibacterial photodynamic therapy in the treatment of oral halitosis

作　　者：刘婧敏 阿丽娜·伊力哈木江 古丽努尔·阿吾提[2,3] LIU Jingmin;Alina·YILIHAMUJIANG;Gulinuer·AWUTI(School of Stomatology,Xinjiang Medical University;Department of Periodontology,the First Affiliated Hospital/Stomatological Hospital of Xinjiang Medical University;Stomatology Disease Institute of Xinjiang Uyghur Autonomous Region,Urumqi 830054,Xinjiang,China)

机构地区：[1]新疆医科大学口腔医学院 [2]新疆医科大学第一附属医院/附属口腔医院牙周病科 [3]新疆维吾尔自治区口腔医学研究所,新疆乌鲁木齐830054

出　　处：《山东大学学报（医学版）》2024年第8期117-124,共8页Journal of Shandong University:Health Sciences

摘　　要：目的探讨抗菌光动力疗法(antimicrobial photodynamic therapy,aPDT)治疗口源性口臭的疗效。方法为了解决“aPDT或aPDT联合刮舌器(tongue scraper,TS)治疗口源性口臭是否比单独用刮舌器更有效”的问题,应用oral halitosis或oral malodor或bad breath和PDT或photodynamic inactivation或photodynamic therapy或photodynamic antimicrobial chemotherapy对PubMed、Cochrane图书馆从建库开始到2024年2月29日的所有文献进行了无语言限制的检索。排除标准包括:非人类实验、体外研究、重复报道的文献、数据不详者、不使用OralChroma^(TM)作为测量仪器的综述、病例报告或实验方案。结果最后纳入了8项随机对照试验,提取数据并进行数据处理后显示:在口臭治疗后立即降低硫化氢浓度方面,aPDT或aPDT+TS比TS具有更好的效果。还有一项研究报告显示:aPDT治疗后细菌载量下降,而TS治疗后细菌载量增加,这表明aPDT对口腔微生物的效果强于TS。结论aPDT或aPDT+TS对口源性口臭有效,但还需要更多、更严谨的试验和更进一步的研究,来探索不同时间间隔下aPDT治疗口源性口臭的临床效果。Objective To explore the efficacy of antimicrobial photodynamic therapy(aPDT)for the treatment of oral halitosis.Methods To address the question of whether aPDT or aPDT combined with a tongue scraper(TS)was more effective than using a tongue scraper alone for the treatment of oral halitosis,an unrestricted language search was conducted on all literature in PubMed and Cochrane libraries from the beginning to February 29,2024,using oral halitosis,oral malodor,bad breath,PDT or photodynamic inactivation or photodynamic therapy.Exclusion criteria included:non-human experiments,in vitro studies,duplicated literature,those with unavailable data,and OralChrome^(TM)was not used as a measurement instrument for reviews,case reports,or experimental protocols.Results Eight randomized controlled trials were included.After data extraction and processing,it was found that aPDT or aPDT+TS had better effects than TS in reducing H_(2)S concentration immediately after halitosis treatment.Another research report showed that the bacterial load decreased after aPDT treatment,while the bacterial load increased after TS treatment,indicating that aPDT had a stronger effect on oral microbiota than TS.Conclusion aPDT or aPDT+TS is effective in treating oral halitosis,but more rigorous experiments and further research are needed to explore the clinical effects of aPDT on oral halitosis at different time intervals.

关 键 词：口臭 光动力疗法 刮舌器 硫化氢 口腔异味 

分 类 号：R781.4[医药卫生—口腔医学]