结直肠癌肝转移外科治疗策略  

Surgical treatment strategies for liver metastasis of colorectal cancer

作　　者：骆洋[1] 顾磊[1] Luo Yang;Gu Lei(Department of Gastrointestinal Surgery,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院胃肠外科,上海200127

出　　处：《国际外科学杂志》2024年第9期582-587,共6页International Journal of Surgery

基　　金：国家自然科学基金项目(81802308)。

摘　　要：近年来,结直肠癌肝转移(CRLM)的治疗手段日益更新,初始可切除CRLM患者手术联合辅助化疗可以达到根治的目的,增加患者无病生存率和总生存率。对于初始不可切除CRLM患者,则需要进行包括化疗联合靶向药物的综合治疗,使肿瘤缩小、降期,转化为可切除肝转移灶。目前,CRLM的规范性、个体化治疗还处于不断探索阶段,尚缺乏有效的循证医学证据支持CRLM的临床精准化治疗。对于每例CRLM患者都需要经过多学科团队讨论,制定个体化的综合治疗方案。In recent years,the methods for treating colorectal cancer with liver metastasis(CRLM)have been increasingly updated,and surgical treatment has become the main means of curing CRLM patients.For patients with high-risk recurrence factors,the application of neoadjuvant chemotherapy can achieve better prognosis.For patients with initial unresectable CRLM,comprehensive treatment is needed to shrink the tumor and transform it into resectable liver metastases.At present,the treatment of CRLM is still in the exploratory stage,and there is a lack of effective evidence-based medicine to support the clinical treatment of CRLM.For each CRLM patient,a multidisciplinary team discussion is required to develop an individualized comprehensive treatment plan.

关 键 词：结直肠肿瘤 外科手术 肿瘤治疗方案 肝转移 新辅助化疗 多学科协作团队 

分 类 号：R735.34[医药卫生—肿瘤]