GPSM2在肿瘤中的研究进展  

Advances in the study of GPSM2 in tumors

作　　者：史友权[1] Shantanu Baral 程一帆 孙倩男 汪刘华 张跃[5] 王道荣 Shi Youquan;Shantanu Baral;Cheng Yifan;Sun Qiannan;Wang Liuhua;Zhang Yue;Wang Daorong(Yangzhou School of Clinical Medicine of Dalian Medical University,Yangzhou 225000,China;Clinical Medical College,Yangzhou University,Yangzhou 225000,China;Northern Jiangsu People′s Hospital,Clinical Teaching Hospital of Medical School,Nanjing University,Yangzhou District,Jiangsu 225000,China;Northern Jiangsu People′s Hospital,Yangzhou 225000,China;Department of Gastrointestinal Surgery,Xuzhou Cancer Hospital,Xuzhou 221000,China)

机构地区：[1]大连医科大学扬州临床医学院,扬州225000 [2]扬州大学临床医学院,扬州225000 [3]南京大学医学院教学医院苏北人民医院,扬州225000 [4]苏北人民医院,扬州225000 [5]徐州市肿瘤医院胃肠外科,徐州221000

出　　处：《国际外科学杂志》2024年第9期640-644,F0004,共6页International Journal of Surgery

基　　金：江苏省卫生健康委员会重点项目(ZD2022047)。

摘　　要：G蛋白信号调节因子2(GPSM2)属于GPSM家族的一员,GPSM2在查德利-麦卡洛综合征、类风湿性关节、系统性红斑狼疮等疾病的发生发展中起着重要作用,并参与非小细胞肺癌、乳腺癌、肝癌、胰腺癌、浆液性卵巢癌、尤文肉瘤和骨肉瘤等肿瘤的增殖、侵袭和转移。目前暂无GPSM2在肿瘤进展机制方面的相关综述。本文将总结了近年来关于GPSM2在肿瘤中的研究进展,重点关注其作用及机制,以期为进一步的研究提供参考和指导。G-protein signaling modulator 2 is a member of the GPSM family,with emerging significance in various diseases including Chadley-McCullough syndrome,rheumatoid arthritis,and systemic lupus erythematosus.Furthermore,its involvement extends to tumor pathogenesis,encompassing non-small-cell lung cancer,breast cancer,hepatocellular carcinoma,pancreatic carcinoma,serous ovarian cancer,Ewing's sarcoma,and osteosarcoma,influencing proliferation,invasion,and metastasis.There is no relevant review on the mechanism of GPSM2 in tumor progression.This paper will summarize the research progress on GPSM2 in tumors in recent years,focusing on its role and mechanism,with the aim of providing references and guidance for further research.

关 键 词：基因 肿瘤 预后 研究 综述 

分 类 号：R730.2[医药卫生—肿瘤]