胃溃疡出血患者胃液PH、EGF、PGE_(2)和胃动素水平与其消化内镜治疗效果及胃肠功能的关系  

The relationship between gastric juice pH, EGF and PGE_(2) levels with the effectiveness of endoscopic treatment and gastrointestinal function in patients with gastric ulcer bleeding

作　　者：帅娟 吴迎[1] 安丽娜 Juan;WU Ying;AN Lina(Comprehensive Medical Department,Central South Hospital,Wuhan University,Wuhan,Hubei 430062,China)

机构地区：[1]武汉大学中南医院综合医疗科,430062

出　　处：《现代消化及介入诊疗》2024年第7期784-788,共5页Modern Interventional Diagnosis and Treatment in Gastroenterology

基　　金：湖北省自然科学基金项目(2022CFB731)。

摘　　要：目的 探讨胃溃疡出血患者胃液PH、表皮生长因子(EGF)和前列腺素E_(2)(PGE_(2))水平与其消化内镜治疗效果及胃肠功能的关系。方法 选取2022年1月至2024年5月于武汉大学中南医院行消化内镜治疗的胃溃疡出血患者67例。对患者消化内镜治疗时收集的胃液中PH、EGF和PGE_(2)水平进行检测。评价患者的疾病治疗有效率。比较不同疗效患者的胃液PH、EGF和PGE_(2)水平,并采用ROC曲线下面积评价其胃液PH、EGF和PGE_(2)水平对消化内镜治疗效果的早期评估效能。收集患者术后肠鸣音恢复时间、肛门排气时间、止血时间、住院时间、溃疡愈合时间等胃肠功能和恢复指标,并通过Pearson相关法分析其胃液PH、EGF和PGE_(2)水平与术后胃肠功能和恢复指标的关系。结果 胃溃疡出血患者67例的临床治疗有效率为71.64%(48/67)。与治疗有效患者比较,治疗无效患者的胃液PH、EGF和PGE_(2)水平均较低(P<0.05)。ROC曲线分析结果显示,胃液PH、EGF和PGE_(2)水平对消化内镜治疗效果均具备一定的预测价值,以三者联合检测的早期评估效能最佳。患者术后肠鸣音恢复时间、肛门排气时间、止血时间、住院时间、溃疡愈合时间分别为(7.16±2.38)min、(26.96±6.41)h、(20.66±4.37)h、(4.52±1.16)d和(23.14±4.18)d。Pearson相关分析结果显示,胃溃疡出血患者胃液PH、EGF和PGE_(2)水平与其术后肠鸣音恢复时间、肛门排气时间、止血时间、住院时间、溃疡愈合时间等胃肠功能和恢复指标均呈负相关(P<0.05)。结论 胃溃疡出血患者胃液PH、EGF和PGE_(2)水平与其消化内镜治疗效果、术后胃肠功能和恢复情况均相关,可作为胃溃疡出血内镜治疗患者疗效的早期评估参考指标。Objective To explore the relationship between relationship between gastric juice pH, epidermal growth factor(EGF) and prostaglandin E_(2)(PGE_(2)) levels with the effectiveness of endoscopic treatment and gastrointestinal function in patients with gastric ulcer bleeding. Methods 67 patients with gastric ulcer bleeding who underwent digestive endoscopy treatment at Zhongnan Hospital of Wuhan University from January 2022 to May 2024 were selected. The levels of pH, EGF and PGE_(2) in gastric juice collected during endoscopic treatment of patients were detected. The effectiveness of disease treatment for patients was evaluated. The levels of gastric juice pH, EGF and PGE_(2) in patients with different therapeutic effects were copared, and the area under the ROC curve was used in the evaluation of gastric juice pH, EGF and PGE_(2) levels in early evaluation of treatment efficacy of digestive endoscopy treatment. The postoperative gastrointestinal function and recovery indicators such as bowel sound recovery time, anal exhaust time, hemostasis time, hospital stay time, and ulcer healing time for patients were selected, and the relationship between postoperative gastrointestinal function and recovery indicators with the levels of gastric juice pH, EGF and PGE_(2) were analyzed by Pearson correlation method and. Results The clinical treatment effectiveness rate of 67 patients with gastric ulcer bleeding was 71.64%(48/67). Compared with those of patients with effective treatment result, patients with ineffective treatment result had lower levels of gastric juice pH, EGF and PGE_(2)(P<0.05). The ROC curve analysis results showed that the levels of gastric juice pH, EGF and PGE_(2) have certain predictive value for the effectiveness of digestive endoscopy treatment, and the combined detection of the three had the best early evaluation efficacy. The postoperative recovery time of bowel sounds, anal exhaust time, hemostasis time, hospital stay time, and ulcer healing time of patients were(7.16±2.38) minutes,(26.96±6.41) ho

关 键 词：胃溃疡出血 胃液 PH 表皮生长因子、前列腺素E_(2) 消化内镜 治疗效果 胃肠功能 关系 

分 类 号：R573.1[医药卫生—消化系统]