真核细胞DNA复制的多层级调控  

Multilayered Regulation of The Eukaryotic DNA Replication

作　　者：张丁峥嵘 刘阳[1] 刘栩豪 胡家志[1] ZHANG-DING Zheng-Rong;LIU Yang;LIU Xu-Hao;HU Jia-Zhi(PKU-THU Center for Life Sciences,School of Life Sciences,Peking University,Beijing 100871,China)

机构地区：[1]北京大学生命科学学院,北大-清华生命科学联合中心,北京100871

出　　处：《生物化学与生物物理进展》2024年第10期2717-2729,共13页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(32122018,323B2010)资助项目。

摘　　要：DNA复制是生命体最基础的代谢过程。在人细胞中,数千个DNA复制源在染色质环境下被同时激活,共同起始DNA复制过程并完成基因组的拷贝。复制过程有组织地进行,既受到染色质环境的约束和调控,又需协调与其他DNA代谢事件的关系,以保证基因组DNA和表观遗传信息准确且稳定地继承。随着研究技术的发展和研究数据的积累,系统性、整体性地研究真核细胞,尤其是哺乳动物细胞,在复杂染色质环境下的DNA复制是未来的研究趋势。本文将从多个角度总结真核DNA复制在染色质环境中的多层级调控模式,期望为今后的研究带来启示。DNA replication is a fundamental DNA metabolism process in living organisms.In human cells,thousands of DNA replication origins are activated simultaneously within the chromatin environment to initiate the replication process and eventually complete genome duplication.This process is regulated by the chromatin environment and coordinated with other chromatin metabolism events,ensuring accurate inheritance of genomic and epigenetic information.With the rapid development of research techniques and the massive accumulation of research data,the systematic understanding of DNA replication in eukaryotic cells,especially in mammals,within complex chromatin environments is a future research trend.Here,we review the multilayered regulatory modes of DNA replication from initiation to termination in the chromatin environment,offering insights for future research.

关 键 词：DNA复制 染色质环境 多层级调控 

分 类 号：Q75[生物学—分子生物学]