Liver microbiome: an intrahepatic resident playing a role in liver diseases  

作　　者：Xindi Ke Qiaoxin Wei Lejia Sun Huayu Yang 

机构地区：[1]Department of Liver Surgery,Peking Union Medical College Hospital(PUMCH),Peking Union Medical College(PUMC)&Chinese Academy of Medical Sciences(CAMS),Beijing,China [2]The Eight-Year MD Program,Peking Union Medical College(PUMC)&Chinese Academy of Medical Sciences(CAMS),Beijing,China [3]Department of Oncology,Beijing You’an Hospital,Capital Medical University,Beijing,China [4]Department of General Surgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing,China [5]The First School of Clinical Medicine,Nanjing Medical University,Nanjing,China

出　　处：《Hepatobiliary Surgery and Nutrition》2024年第4期686-689,共4页肝胆外科与营养（英文）

基　　金：Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(CIFMS)(No.2021-I2M-1-058).

摘　　要：The commensal microbiome has been shown to exhibit intimate associations with human health and diseases.Harboring abundant microbes,the gut is involved in regulating the physical and pathological status of liver,including hepatic function,inflammation,immunity,metabolism,regeneration,etc.(1,2).Although it has been proposed in the gut-liver axis theory that the gut microbes and their metabolites could be disseminated into liver through the portal vein system,particularly in the conditions of gut microbiota dysbiosis and intestinal barrier dysfunction(3),the liver microbiome has only been confirmed and characterized in recent years.In this article,we reviewed the latest research advancements pertaining to the liver microbiome,discussed its potential clinical implications,and further explored the promising avenues for future research in this field(Figure 1).

关 键 词：Liver microbiome hepatocellular carcinoma(HCC) non-alcoholic fatty liver disease(NAFLD) immunity inflammation 

分 类 号：R575[医药卫生—消化系统]