Trimming the fat myth: adipose tissue’s role in liver regeneration  

作　　者：Andrea Peloso Nicolas Golse 

机构地区：[1]Hepato-Biliary Center,Paul-Brousse Hospital,Assistance Publique-Hôpitaux de Paris,Villejuif,France [2]Division of Transplantation and Abdominal Surgery,Department of Surgery,Geneva University Hospitals and Faculty of Medicine,Geneva,Switzerland [3]UMRS 1193,Paris-Saclay University,Inserm,Pathogenesis and Treatment of Liver Diseases,FHU Hepatinov,Villejuif,France

出　　处：《Hepatobiliary Surgery and Nutrition》2024年第4期727-731,共5页肝胆外科与营养（英文）

摘　　要：We read with great interest the paper from Jena(Germany)recently published in Hepatobiliary Surgery and Nutrition by Deeb et al.,which caught our attention,given its clinical relevance.In fact,post-hepatectomy liver failure(PHLF)remains nowadays a significant clinical challenge,occasionally leading to death or potentially requiring,in highly selected cases,rescue liver transplantation(1).Within quaternary care centers,the incidence of PHLF fluctuates from 5%to 20%,depending on the criteria employed,the underlying liver parenchyma quality and the type of hepatectomy(2).Hence,liver regeneration(LR)holds paramount importance in hepatic surgery as it directly impacts post-operative outcomes(3):it is a strictly orchestrated phenomenon that entails the activation of hepatocytes and hepatic progenitor cells,as well as the regulation of cell-cycle genes and growth factors.Features contributing to PHLF include pre-operative,intra-operative and post-operative elements,leading to careful patient selection(4).

关 键 词：Liver regeneration(LR) adipose tissue liver living-donor transplantation 

分 类 号：R575[医药卫生—消化系统]